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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Review publication

Data source

Reference
Reference Type:
review article or handbook
Title:
Safety assessment of glycolic acid, ammonium, calcium, potassium, and sodium glycolate, methyl, ethyl, ptopyl, and butyl glycolate, and lactic acid, ammonium calcium, potassium, sodium, and TEA-lactate, methyl, ethyl, isopropyl, and butyl lactate, and
Author:
Andersen, F.A.
Year:
1997
Bibliographic source:
Cosmetic Ingredients Review, final report. International Journal of Toxicology, Vol.17, Suppl.1.

Materials and methods

Type of study / information:
Type of experience: Human

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): Lactic acid

Results and discussion

Applicant's summary and conclusion

Conclusions:
The maximisation tests performed with human subjects showed no skin sensitisation upon exposure to cosmetic formulations containing 6-10% lactic acid (pH 3.7-4.2).

Lactic acid is a natural endogenous metabolite produced by humans and animals. Normal human blood contains 8-17 mg lactic acid/100 mL plasma. The concentration of lactate is found higher on the normal human skin than in the blood due to glycolytic enzymes that actively convert glucose to lactic acid in the epidermis.