C-C1

Partition coefficient

Administrative data

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

27th March 2007 to 19th April 2007

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2007

Report date:

2007

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient)

Deviations:

no

GLP compliance:

yes

Remarks:

Date of inspection: 30th August 2005 Date of signature; 21st November 2005

Type of method:

shake-flask method to: flask method

Partition coefficient type:

octanol-water

Test material

Reference

Name:

Unnamed

Type:

Constituent

Details on test material:

Sponsor's identification :C-C1
Description : dark blue powder
Lot number : MB-1
Date received : 05 March 2007
Storage conditions :room temperature in the dark, over silica gel

Study design

Analytical method:

high-performance liquid chromatography

Results and discussion

Partition coefficient

Type:

log Pow

Partition coefficient:

< -2.58

Temp.:

23 °C

pH:

7

Any other information on results incl. tables

 Preliminary estimate

Approximate solubility in n-octanol:<1.20 x 10^-2 g/l
Approximate solubility in water:      >217 g/l
Approximate P_ow:  <5.54 x 10^-5
Log₁₀ P_ow:  < -4.26

Applicant's summary and conclusion

Conclusions:

The partition coefficient of the test material has been determined to be <2.61 x 10-3 at 23.0 ± 0.5°C, log10 Pow < -2.58.

Executive summary:

The determination was carried out using the shake-flask method, Method A8 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC) and Method 107 of the OECD Guidelines for Testing of Chemicals, 27 July1995.

The partition coefficient of the test material has been determined to be <2.61 x 10^-3at 23.0 ± 0.5°C, log₁₀P_ow < -2.58.