Registration Dossier

Diss Factsheets

Administrative data

vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Testing was conducted between 03 April 2007 and 24 April 2007.
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not effect the quality of the relevant results.

Data source

Reference Type:
study report
Report date:

Materials and methods

Test guidelineopen allclose all
according to guideline
EU Method A.4 (Vapour Pressure)
according to guideline
OECD Guideline 104 (Vapour Pressure Curve)
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance

Test material

Details on test material:
Sponsor's identification :C-Y9
Description : yellow powder
Lot number : MB-1
Date received : 06 March 2007
Storage conditions :room temperature in the dark over silica gel.

Results and discussion

Vapour pressure
25 °C
Vapour pressure:
< 0 Pa

Any other information on results incl. tables

See attached background material for results of runs 1 - 4.


No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25ºC.

Run 4 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 249ºC (522.15 K) was chosen because this is the data point which gives the highest estimated vapour pressure at any given temperature when a slope of –1500 K is imposed upon it.

The value of –1500 K is an in-house value and is the shallowest slope observed whilst determining the vapour pressure on a wide range of samples using the vapour pressure balance method. Extrapolation to 25ºC gave a vapour pressure of 1.726 x 10-5Pa which has been taken as a maximum for this material.

The test material did not change in appearance under the conditions used in the determination.

The vapour pressure of the test material has been determined to be less than 1.8 x 10-5Pa at 25ºC.

Applicant's summary and conclusion

The vapour pressure of the test material has been determined to be less than 1.8 x 10-5 Pa at 25ºC.
Executive summary:

The vapour pressure was determined using a vapour pressure balance with measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25°C. Testing was conducted using Method A4 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC), and Method 104 specified in the OECD Guidelines for Testing of Chemicals, 25 March 2006.

The vapour pressure of the test material has been determined to be less than 1.8 x 10-5 Pa at 25ºC.