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EC number: 439-840-1 | CAS number: 20846-91-7
The closely-related material trisodium EDDS was assessed for its ability to induce skin irritation in a 24-h repeat application patch test in twelve healthy volunteers.
After swabbing the skin of the upper arm with alcohol to remove any surface oils, 0.4 mL each of 2.94, 14.7 and 29.41% aqueous solutions of test substance were applied in Hill Top chambers to separate sites on the skin of the upper arm. After 24 h the patches were removed and the test sites were washed with water to remove any residue substance. Patches were applied on Friday, Monday and Wednesday, leaving at least 24 h after removal of the previous patch. The test sites were graded, both visually and colorimetrically before each application and 24 h after removal of the third patch. No signs of irritation were evident in any of the volunteers at any time point.
In conclusion, trisodium EDDS showed no evidence of skin irritating potential in a 24-h human repeat application patch test.
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