GASIR1

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

transformation / dissolution of metals and inorganic metal compounds

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Qualifier:

according to guideline

Guideline:

OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media

Principles of method if other than guideline:

The extend of dissolution of Gasir 1 in (adapted) ISO 6341 medium was determined via a simple experimental procedure of agitating various quantities of the test item in pH buffered aqueous media (pH 6, 7.8, and 8.5). Gasir 1 was introduced into the aqueous medium at single loadings of 100 mg/L each. The mixtures were agitated during a 24-hours period and the concentration of dissolved Se, Ge, As, and Sb were measured.

GLP compliance:

no

Type of method:

other: Transformation/dissolution of metals

Type of test:

screening transformation/dissolution test - sparingly soluble metal compounds

Mean dissolved conc.:

2.56 µg/L

Element analysed:

Ge

Loading of aqueous phase:

100 mg/L

Incubation duration:

24 h

Test conditions:

pH 6

Type of test:

screening transformation/dissolution test - sparingly soluble metal compounds

Mean dissolved conc.:

1.18 µg/L

Element analysed:

As

Loading of aqueous phase:

100 mg/L

Incubation duration:

24 h

Test conditions:

pH 6

Type of test:

screening transformation/dissolution test - sparingly soluble metal compounds

Mean dissolved conc.:

1.24 µg/L

Element analysed:

Se

Loading of aqueous phase:

100 mg/L

Incubation duration:

24 h

Test conditions:

pH 6

Type of test:

screening transformation/dissolution test - sparingly soluble metal compounds

Mean dissolved conc.:

30.23 µg/L

Element analysed:

Ge

Loading of aqueous phase:

100 mg/L

Incubation duration:

24 h

Test conditions:

pH 7.8

Type of test:

screening transformation/dissolution test - sparingly soluble metal compounds

Mean dissolved conc.:

0.41 µg/L

Element analysed:

As

Loading of aqueous phase:

100 mg/L

Incubation duration:

24 h

Test conditions:

pH 7.8

Type of test:

screening transformation/dissolution test - sparingly soluble metal compounds

Mean dissolved conc.:

10.35 µg/L

Element analysed:

Se

Loading of aqueous phase:

100 mg/L

Incubation duration:

27 h

Test conditions:

pH 7.8

Type of test:

screening transformation/dissolution test - sparingly soluble metal compounds

Mean dissolved conc.:

23 µg/L

Element analysed:

Ge

Loading of aqueous phase:

100 mg/L

Incubation duration:

24 h

Test conditions:

pH 8.5

Type of test:

screening transformation/dissolution test - sparingly soluble metal compounds

Mean dissolved conc.:

16 µg/L

Element analysed:

As

Loading of aqueous phase:

100 mg/L

Incubation duration:

24 h

Test conditions:

pH 8.5

Type of test:

screening transformation/dissolution test - sparingly soluble metal compounds

Mean dissolved conc.:

15 µg/L

Element analysed:

Se

Loading of aqueous phase:

100 mg/L

Incubation duration:

24 h

Test conditions:

pH 8.5

Details on results:

The highest solubility of GASIR1 after 24-h agitation at 200 rpm was observed at pH 8.5. Maximum dissolved concentrations for Ge, As and Se were 23, 16 and 15 µg/l, respectively.
There was a remarkable abrasion visible in the test containers after 24 h.

Conclusions:

Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The highest solubility of GASIR1 (loading of 100 mg/l) after 24-h agitation at 200 rpm was observed at pH 8.5. Maximum dissolved concentrations for Ge, As and Se were 23, 16 and 15 µg/l, respectively.

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

04/02/2005-24/2/2005

Reliability:

2 (reliable with restrictions)

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes

Type of method:

column elution method

Water solubility:

< 0.1 mg/L

Temp.:

20 °C

pH:

ca. 6.3

Details on results:

As all the samples showed no significant intensity for each element compared to the blank solution (glass double-distilled water), and all intensities were less than that of the relevant lowest standard (0.1 mg/l), the results were quoted as less than 1.0 x 10-4 g/l for each element analysed.

Conclusions:

Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility of each of element of the test material has been determined to be less than 1.0 x 10-4 g/l of solution at 20.0 ± 0.5°C.

Executive summary:

Less than 1.0 x 10-4 g/l of solution for each element at 20.0 ± 0.5°C, using the column elution method, Method A6 of Commission Directive 92/69/EEC.

Reference 3

Endpoint:

transformation / dissolution of metals and inorganic metal compounds

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: The report is not sufficiently documented: no description of the tested substance, no description of analytical method, etc.

Qualifier:

according to guideline

Guideline:

OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media

Deviations:

yes

Remarks:

loading of 0.25 g/l

GLP compliance:

no

Type of method:

other: Transformation/dissolution of metals

Type of test:

full transformation/dissolution test - metals and sparingly soluble metal compounds

Mean dissolved conc.:

< 0.5 µg/L

Element analysed:

Ge

Loading of aqueous phase:

250 mg/L

Incubation duration:

7 d

Test conditions:

pH 8.5

Type of test:

full transformation/dissolution test - metals and sparingly soluble metal compounds

Mean dissolved conc.:

< 0.5 µg/L

Element analysed:

As

Loading of aqueous phase:

250 mg/L

Incubation duration:

7 d

Test conditions:

pH 8.5

Type of test:

full transformation/dissolution test - metals and sparingly soluble metal compounds

Mean dissolved conc.:

< 0.5 µg/L

Element analysed:

Se

Loading of aqueous phase:

250 mg/L

Incubation duration:

7 d

Test conditions:

pH 8.5

Details on results:

After 168-h agitation of GASIR1 in the modified ISO 6341 medium at pH 8.5, dissolved concentrations for all elements (Ge, As and Se) were below 0.5 ug/l for the 250 mg/l loading.

Conclusions:

Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
After 168-h agitation of GASIR1 in the modified ISO 6341 medium at pH 8.5, dissolved concentrations for all constituents (Ge, As and Se) were below 0.5 µg/l for the 250 mg/l loading.

Description of key information

Assessment of the water solubility according to EU method A6 and the extent of dissolution according to OECD29 illustrate that Gasir 1 is highly insoluble.

 

 

Additional information

The Transformation / Dissolution 24-h screening study according to OECD29 is reliable and can be used as key study for this endpoint. In the 24-h screening the highest solubility of GASIR1 (loading of 100 mg/l) was observed at pH 8.5. Maximum dissolved concentrations for Ge, As and Se were 23, 16 and 15 µg/l, respectively.

 

Supporting studies:

 

Cuthbert JE & Mulle DM(2005) is a GLP-compliant study following EU method A6. The water solubility of the test item at 20 °C was determined to be < 0.1 mg/l (loadiing of 10 mg/L).

 

In a Transformation/Dissolution 168-h test (Rodriguez PH (2007)) at pH 8.5, at a loading rate of 250mg/L, dissolved concentrations for all constituents (Ge, As and Se) were below 0.5 µg/l for the 250 mg/l loading.

 

 

Interpretation of results: insoluble (< 0.1 mg/L).