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EC number: 443-050-2 | CAS number: 120903-40-4 PERFLUOROHEXANE NITRILE VINYL ETHER
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
The partition coefficient of the hydrolysis product MV5CN amide is 4.0 (OECD 105)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4
- at the temperature of:
- 20 °C
Additional information
MV5CN is hydrolytically active. The n-Octanol/Water Partition Coefficient (log Kow) of the hydrolysis product MV5CN amide was determined according to OECD 107 “Partition Coefficient (n-Octanol/Water), Shake Flask Method” and EPA OPPTS 830.7550 "Partition Coefficient (n-Octanol/Water), Shake Flask Method". Duplicate samples of test material were prepared in each of the three octanol/water ratios (1:1, 1:2, and 2:1). The total volume was 12 mL. The test vessels were dosed at 1.90 mg. All test vessels were shaken for 30 minutes. The test vessels were centrifuged at a setting of 16421g and 20 °C for 5 minutes to ensure phase separation. Aliquots from n-octanol phase were removed, diluted with acetonitrile then diluted further with 50:50(v/v) acetonitrile/water. Aliquot of water phase sample were diluted in 1:1 (v:v) ratio with acetonitrile. All samples were analyzed using Ultra performance liquid chromatography/Tandem mass spectrometer (UPLC-MS/MS). Total recovery of test material from both phases was 99-103%.
The average measured Kow was 9700 (SD = 360) which corresponds to a log Kow of 4.0.
This was a guideline study conducted under GLP compliance. Therefore, it is considered reliable without restrictions.
An additional study was done on the parent material using the ratio of solubility in n-octanol and water. No guideline exists for measurement of octanol solubility. Per Chapter R.7a of Guidance on Information Requirements and Chemical Safety Assessment, the general principles of OECD TG105 (water solubility) apply to octanol solubility measurement. The n-octanol solubility of MV5CN was determined in 2002 according to EU Method A.8 (Flask Method) and was compliant with GLP criteria. However, the water solubility could not be determined as the concentration was below the limit of detection (<0.4 mg/L). The average n-octanol solubility was determined to be 17.5 g/L. The log Pow of the test substance at room temperature was calculated to be >4.6. Since the water solubility value wasn't clearly defined due to detection limitations, the study is considered reliable with restriction
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