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EC number: 482-140-6 | CAS number: 13641-96-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 Feb 2011 - 04 Mar 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- adopted in 2009
- Deviations:
- yes
- Remarks:
- whole-body exposure although liquids aerosols were tested, particle size (MMAD) not determined, chamber conditions and age of animals not provided, not GLP
- GLP compliance:
- no
- Remarks:
- The study was performed to meet the requirements of a non-EU Regulatory Authority. A quality assurance statement was included.
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 482-140-6
- EC Name:
- -
- Cas Number:
- 13641-96-8
- Molecular formula:
- Hill formula: C6 H7 N O3 CAS formula: C6 H7 N O3
- IUPAC Name:
- 2-isocyanatoethyl prop-2-enoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Shanghai SLAC Laboratory Animal Co., Ltd.
- Females nulliparous and non-pregnant: yes
- Weight at study initiation: 260 - 300 g
- Housing: Animals in each group were housed in a power exposure chamber
- Diet: standard diet, ad libitum (changed weekly)
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 25
- Humidity (%): 40 - 70
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 22 Feb 2011 To: 15 Mar 2011
Administration / exposure
- Route of administration:
- inhalation: mist
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Remark on MMAD/GSD:
- The mass median aerodynamic diameter (MMAD) was not determined.
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus:
power exposure chamber (Tianjin Hepu Co., Ltd.)
- Exposure chamber volume: 300 L
- System of generating particulates/aerosols:
The test substance was sprayed to the chamber with a sprayer.
- Method of particle size determination:
The particle size was not measured.
TEST ATMOSPHERE
- Brief description of analytical method and equipment used:
Every half an hour, the average of concentration of the sample in an atmosphere was estimated by adsorbing the sample onto silica gel, desorbing the sample with acetone and analysing it by gas chromatography.
VEHICLE
A group of animals (5 males and 5 females), which were exposed to air, served as the control group.
TEST ATMOSPHERE
- Particle size distribution:
Not measured.
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.):
Not determined. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 18.15, 51.18, 117.20, 240.62 and 483.59 mg/m³
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Remarks:
- exposed to air
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed once daily. Body weight was measured once a week.
- Necropsy of survivors performed: yes
- Clinical signs including body weight: yes - Statistics:
- Statistical analysis were not performed.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 53.72 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- Mortality occurred as follows:
18.15 mg/m³: 0/5 males and 0/5 females
51.18 mg/m³: 2/5 males and 2/5 females
117.20 mg/m³: 5/5 males and 5/5 females
240.62 mg/m³: 5/5 males and 5/5 females
483.59 mg/m³: 5/5 males and 5/5 females - Clinical signs:
- other: moist hair, cachexia, slow breathing, agitation, high sensitivity, salivation, scratching and combing
- Remarks:
- For details, please refer to the attached background material 1.
- Body weight:
- All animals gained body weight during the study.
- Gross pathology:
- Gross necropsy did not reveal any obvious abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- other: As the test atmosphere was judged as mist and according to the CLP Regulation (EC) No 1272/2008, classification for acute Tox. 2 (H330) is required.
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