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EC number: 411-950-4 | CAS number: 96562-58-2 DHPPME; MAK-ME; MEHPOPS; R-MAQ-ME
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
Description of key information
Campbell et al. (1993):Under the conditions of this study, the fat solubility of the test material was determined to be 82.57 g/kg HB307 standard fat.
Böck (1991): Under the conditions of this study, the solubility of the test material in standard fat is 9320 mg/100 g fat at 37 °C.
Key value for chemical safety assessment
- Solubility in mg/100g standard fat:
- 9 320
- At the temperature of:
- 37 °C
Additional information
Two studies are available to address this endpoint and both are considered to be key as the data are equally reliable. The studies were assigned a reliability score of 1 in accordance with the criteria for assessing data quality set forth by Klimisch et al. (1997).
Campbell et al. (1993)
The fat solubility of the test material was investigated in accordance with the standardised guidelines OECD 116 and EU Method A.7 under GLP conditions.
Ten times the amount of the Saturation Mass Fraction of the test material as determined in the preliminary test was weighed into 8 flasks. To each flask, ca. 25 g of HB307 standard fat was accurately weighed. Four flasks were shaken at 30 °C and 4 at 50 °C in an orbital water bath. After 1 hour both groups were moved to a bath set at 37 °C and shaken further. Two flasks from each group were removed after 6 days and left to stand at 37 °C until sampled for analysis. An aliquot of the supernatant was removed, centrifuged and analysed. The remaining 2 flasks from both groups were shaken for a further 24 hours before removal from the orbital water bath, and treated in the same manner as the first set of samples.
Under the conditions of this study, the fat solubility of the test material was determined to be 82.57 g/kg HB307 standard fat.
Böck (1991)
The fat solubility of the test material was determined in accordance with the standardised guideline EU Method A.7 under GLP conditions.
UV spectrometry was used to determine the measured amount of test material compared to the weight amounts of the test material in chloroform following filtration of pre-saturated two phase solid-liquid mixtures of the test material and fat.
Under the conditions of this study, the solubility of the test material in standard fat is 9320 mg/100 g fat at 37 °C.
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