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EC number: 460-390-7 | CAS number: 26504-29-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, OECD n°423 guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 460-390-7
- EC Name:
- -
- Cas Number:
- 26504-29-0
- Molecular formula:
- C15H14S3
- IUPAC Name:
- bis(benzylsulfanyl)methanethione
- Details on test material:
- - Name of test material (as cited in study report): DIBENZYL TRITHIOCARBONATE
- Physical state: yellow orange-colored solid
- Analytical purity: 96.2
- Purity test date: 2003-10-27
- Lot/batch No.: 1 UG 114
- Expiration date of the lot/batch: November 2004
- Storage condition of test material: at room temperature and protected from light
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: approx. 8 weeks old
- Weight at study initiation: 281 ± 19 g for the males and 198 ± 4 g for the females
- Fasting period before study: yes (18 hours before administration)
- Housing: 3 rats of the same sex per polycarbonate cage (48x27x20cm)
- Diet (e.g. ad libitum): ad libitum A04C pelleted diet (U.A.R., 91360 Villemoisson sur Orge, France)
- Water (e.g. ad libitum): ad libitum drinking water filtered by a FG Millipore membrane (0.22µ)
- Acclimation period: > 5days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/- 2
- Humidity (%): 30-70
- Air changes (per hr): approx. 12
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20 or 200 mg/ml
- Justification for choice of vehicle: solubility
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg - Doses:
- 200 and 2000 mg/kg
- No. of animals per sex per dose:
- 3/sex at 2000 mg/kg and 3 males at 200 mg/kg
- Control animals:
- no
- Details on study design:
- CLINICAL EXAMINATIONS
The single administration was performed in the morning of day 1; it was followed by a 14-day observation period.
Clinical signs and mortality:
The animals were observed frequently during the hours following administration of the test item, for detection of possible treatment-related clinical signs. Thereafter, observation of the animals was made at least once a day.
Type, time of onset and duration of clinical signs were recorded for each animal individually.
Body weight:
The animals were weighed individually just before administration of the test item on day 1 and then on days 8 and 15.
The body weight gain of the treated animals was compared to that of CIT control animals with the same initial body weight.
PATHOLOGY
Sacrifice:
On day 15, all animals were killed by carbon dioxide asphyxiation.
Macroscopic necropsy examination:
All study animals were subjected to a macroscopic examination as soon as possible after death.
After opening the thoracic and abdominal cavities, a macroscopic examination of the main organs (digestive tract, heart, kidneys, liver, lungs, pancreas, spleen and any other organs with obvious abnormalities) was performed.
Preservation of tissues:
No organ samples were taken. - Statistics:
- The interpretation of results was based on the flow charts of Annex 3 of the OECD Guideline No. 423, 22 March 1996.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Mortality:
- No mortality was observed at 200 and 2000mg/kg
- Clinical signs:
- other: No clinical signs was observed in the animals given 200 mg/kg. At the 2000 mg/kg dose-level, no clinical signs were noted in males. In females, piloerection and dyspnea, together with hypoactivity and rhinorrea in 2/3 animals on day 1, were observed in al
- Gross pathology:
- Macroscopic examination of the main organs of the animals revealed no apparent abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008
- Conclusions:
- The oral LD0 of DIBENZYL TRITHIOCARBONATE is higher than or equal to 2000 mg/kg in rats.
- Executive summary:
The acute oral toxicity of DIBENZYL TRITHIOCARBONATE was evaluated in rats according to OECD N°423 guideline (December 17th2001).DIBENZYL TRITHIOCARBONATE was administered by oral route (gavage at 200 and 2000 mg/kg) to groups of 3 male and/or female fasted Sprague-Dawley rats.
No clinical signs and no mortality were observed in the animals given 200 mg/kg. At the 2000 mg/kg dose-level, no mortality occurred. No clinical signs were noted in males. In females, piloerection and dyspnea, together with hypoactivity and rhinorrea in 2/3 animals on day 1, were observed in all animals on days 1 and 2. The overall body weight gain of the animals given 200 mg/kg was not affected by treatment with the test item. The body weight gain of the males given 2000 mg/kg was slightly reduced during the first week of the study, when compared to historical control animals. The overall body weight gain of the females treated at 2000 mg/kg was similar to that of historical control animals. At necropsy, no apparent abnormalities were observed.
Under these experimental conditions, the oral LD0 of DIBENZYL TRITHIOCARBONATE in rat is higher than or equal to 2000 mg/kg in rats.
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