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EC number: 205-517-7 | CAS number: 141-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction:US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- ECOSAR Program (v1.00)
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- other: earthworm
- Animal group:
- other: QSAR model
- Study type:
- other: QSAR
- Substrate type:
- other: QSAR
- Limit test:
- no
- Total exposure duration:
- 14 d
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Moisture:
- not applicable. QSAR model
- Details on test conditions:
- SMILES : O(C(=NCC)S)C(C)C
CHEM : Carbamothioic acid, ethyl-, O-(1-methylethyl) ester
CAS Number: 141-98-0
MOL FOR: C6 H13 N1 O1 S1
MOL WT : 147.24
Log Kow: 3.32 (KowWin estimate)
Wat Sol: 114.4 mg/L (WskowWin estimate) - Reference substance (positive control):
- no
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 186.87 mg/kg soil ww
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Remarks on result:
- other: 1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
- Details on results:
- LC50 (14-day, earthworm)= 186.870 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)=186.870 mg/kg soil dw - Reported statistics and error estimates:
- US EPA accepted QSAR method for chemicals properties assessment.
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- LC50 (14-day, earthworm)= 186.870 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)=186.870 mg/kg soil dw - Executive summary:
The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm) would to be 186.870 mg/L (ppm).
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 186.870 mg/kg soil dw
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/ O-isopropyl ethylthiocarbamate . Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate .
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Caenorhabditis elegans
- Animal group:
- nematods
- Details on test organisms:
- SPECIES #
(NAME): 4550 Caenorhabditis elegans
(Nematode)
AGE: NR NR
LIFE STAGE: larva(e)
COMMENT: NR - Study type:
- laboratory study
- Substrate type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 24 h
- Test temperature:
- not reported
- pH:
- not reported
- Moisture:
- not reported
- Details on test conditions:
- 6.55 % v/v percent volume per volume
- Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 6.55 other: % v/v
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: % v/v - percent volume per volume
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 6.7 other: % v/v
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: % v/v - percent volume per volume
- Details on results:
- A 24 h LC50 of 6.5 to 6.6 % v/v - percent volume per volume has been determined for mortality to Caenorhabditis elegans of the test substance.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- A 24 h LC50 of 6.5 to 6.7 % v/v - percent volume per volume has been determined for mortality to Caenorhabditis elegans of the test substance.
Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol. Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate .
Referenceopen allclose all
Overview of QSARs estimations on toxicity of O-isopropyl ethylthiocarbamate (IPETC ) to soil macroorganisms
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
LC50 (14-day, earthworm)= 186.870 mg/L (ppm)
|
Reliable withrestrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
LC50 (14-day, earthworm)= 186.870 mg/kg soil dw
The toxicities of 4 short-chain alcohols--namely methanol, ethanol, iso-propanol and iso-butanol--were compared in the nematode Caenorhabditis elegans using several different ecotoxicological endpoints. Range-finding tests were conducted using transgenic PC161 worms carrying a double reporter construct (GFP plus lacZ) linked to the stress-inducible hsp16-1 promoter. These tests showed little response from the GFP reporter, but gave good dose-response curves for the lacZ reporter--showing clear induction at 0.5% v/v ethanol in an overnight assay, but only at 4% in a shorter 6-h assay.
Comparison of the short-term dose-response curves shows a confusing pattern of differences between the four alcohols tested, although dose-dependence is evident across at least part of the concentration range. Feeding inhibition assays are somewhat inconclusive with regard to alcohol type, although iso-butanol and iso-propanol appear more toxic than ethanol, while methanol is least toxic. To resolve some of the remaining ambiguities, we also used a fecundity assay to show that iso-propanol is more toxic than ethanol, and a lethality assay to show that iso-butanol is more toxic than iso-propanol.
Most of the endpoints studied are consistent with the following order of toxicity: iso-butanol > iso-propanol > ethanol > or = methanol.
Description of key information
The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm) would to be 186.870 mg/L (ppm).
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 186.870 mg/kg soil dw
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 186.87 mg/kg soil dw
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 37.374 mg/kg soil dw
Additional information
The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm) would to be 186.870 mg/L (ppm).
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 186.870 mg/kg soil dw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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