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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 03 March 2020 and 31 March 2020.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study is considered to be a reliability 1 as it has been conducted according to OECD Test Guideline 301F using a Manometric Respirometry method and in compliance with GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction mass of 2(R/S)‐1‐{[(1R,2S,5R,8S)‐4,4,8‐trimethyltricyclo[6.3.1.0~2,5~]dodecan‐1‐yl]oxy}pentan‐2‐o and 2(R/S)‐1‐{[(1S,2S,5R,8R)‐1,4,4‐trimethyltricyclo[6.3.1.0~2,5~]dodecan‐8‐yl]oxy}pentan‐2‐ol
- Molecular formula:
- C20H36O2
- IUPAC Name:
- Reaction mass of 2(R/S)‐1‐{[(1R,2S,5R,8S)‐4,4,8‐trimethyltricyclo[6.3.1.0~2,5~]dodecan‐1‐yl]oxy}pentan‐2‐o and 2(R/S)‐1‐{[(1S,2S,5R,8R)‐1,4,4‐trimethyltricyclo[6.3.1.0~2,5~]dodecan‐8‐yl]oxy}pentan‐2‐ol
- Test material form:
- liquid: viscous
- Details on test material:
- Chemical name: 1‐[(4,4,8‐trimethyltricyclo[6.3.1.02,5]dodecan‐1‐yl)oxy]pentan‐2‐ol and 1‐[(1,4,4‐trimethyltricyclo[6.3.1.02,5]dodecan‐8‐yl)oxy]pentan‐2‐ol and isomers
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- Activated sludge was obtained as the test inoculum from a sewage plant treating predominantly domestic sewage (Nanjing Tiebei Sewage Treatment Plant). On return to the laboratory, coarse particles were removed by filtration through a fine sieve and the sludge aerobic will be kept thereafter for 5-7 days at the test temperature.
- Duration of test (contact time):
- ca. 28 d
Initial test substance concentration
- Initial conc.:
- > 50 - < 100 other: mg/L
- Based on:
- COD
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- The vessels will be allowed to reach the desired temperature and appropriate vessels will be inoculated with prepared activated sludge to give a concentration of suspended solids at 30 mg/L.
Addition of Test Substance – appropriate amount of test substance will be added into test bottles of “test” (bottle 1&2) and “Inhibition control” (bottle 6).
Addition of Reference Substance – 10 mL of the reference control stock solution of Sodium benzoate (1000 mg/L) will be added into test bottles of “procedure control” (bottle 5) and “Inhibition control” (bottle 6) to give a final concentration of 40 mg/L, respectively.
Addition of Inoculums – 1.875 mL of Inoculums suspended solids will be added into “test” (bottle 1&2), “inoculum control” (bottle 3&4), “procedure control” (bottle 5) and “Inhibition control” (bottle 6) to give a concentration of 30 mg/L.
Basal Salts Medium (BSM) will be added to every test bottle to get a final volume of 250 mL.
The equipment will be assembled, the stirrer started, the equipment checked that it is air-tight, and the measurement of oxygen uptake will be started (Time zero). Carbon dioxide produced metabolically by the bacteria is chemically bound by the sodium hydroxide solution contained in the seal cup in the bottle. Usually no further attention is required other than taking the necessary readings and making daily checks to see that the correct temperature and adequate stirring are maintained. According to the readings of automatic respirometer, a continuous record of oxygen uptake is obtained so that the 10-d window is easily recognized.
The oxygen uptake will be calculated from the readings taken at least daily, using the methods given by the manufacturer of the equipment.
At the beginning and the end of incubation, normally 28 days, the pH of the contents of the flasks will be measured
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 95
- Sampling time:
- 28 d
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Under the valid conditions, biodegradation of the FRET 18-0091 was 95.0% at the end of the 28-day study.
- Executive summary:
Under the valid conditions, biodegradation of the FRET 18-0091 was 95.0% at the end of the 28-day study.
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