2-methyl-3-(p-tolyl)propionaldehyde

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

July 25, 1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

No guideline available in the report as the test has been performed prior to the OECD guideline.
This acute dermal toxicity study involved ten rabbits that were given a single oral dose of 5000 mg test material/kg bw. Mortality, toxic signs and skin irritation were monitored during the study.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-methyl-3-(p-tolyl)propionaldehyde

EC Number:

255-410-4

EC Name:

2-methyl-3-(p-tolyl)propionaldehyde

Cas Number:

41496-43-9

Molecular formula:

C11H14O

IUPAC Name:

2-methyl-3-(4-methylphenyl)propanal

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Duration of exposure:

Single exposure

Doses:

5 g/kg

No. of animals per sex per dose:

10 animals per dose (sex not specified)

Control animals:

no

Statistics:

Not performed

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

Death occurred between the day 2 and 7 after treatment.
See the table of results below.

Clinical signs:

other: Toxic signs: slight lethargy.

Gross pathology:

Some effects were reported on the lungs (dark areas), liver (dark, mottled or white are-as at all doses) and intestines (red and grey areas).

Other findings:

Skin irritation:
- mild redness in 3 rabbits, moderate redness in 2 rabbits and severe redness in 5 rabbits
- moderate edema in 9 rabbits and severe edema in 1 rabbit

Any other information on results incl. tables

Results

Doses g/kg	Mortality	Day of death: 0	Day of death: 1	Day of death: 2	Day of death: 3	Day of death: 7
5.0	3/10	n/a	n/a	1	1	1

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Under the test conditions of this study, the dermal LD50 of the test substance in rabbits was estimated to be greater than 5000 mg/kg bw.
Therefore, the test material is not classified according to the GHS, as the LD50 value is greater than 5000 mg/kg bw.

Executive summary:

In an acute dermal toxicity study, ten rabbits were given a single dose of 5000 mg test material/kg bw.

Mortality, toxic signs and skin irritation were monitored during the study.

Death occurred between the day 2 and 7 after treatment. Signs of slight lethargy were observed. Redness (from mild to severe) and edema (from moderate to severe) were also recorded in the rabbits during the course of the study.

Dermal LD50 > 5000 mg/kg bw

The LD50 of the test substance to rabbits (sex unspecified) was found to be > 5000 mg/kg bw. Considering the relative density of the substance, the dermal LD50 of the test substance to rabbits was estimated to be > 5000 mg/kg bw.

Therefore, the test material is not classified according to the GHS, as the LD50 value is greater than 5000 mg/kg bw.