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EC number: 274-533-4 | CAS number: 70285-70-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 - 17 December 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Commission Regulation (EC) No 440/2008 of 30 May 2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)
- Deviations:
- no
- Principles of method if other than guideline:
- Due to the very high water solubility of the test item, estimated in a preliminary test, a modified test design was applied based on the OECD 105 guideline. Instead of equilibrating a large amount of test item with water by stirring over several days and subsequently separating the test item from the saturated solution, water was added in a stepwise procedure to a defined amount of test item until complete dissolution occurred.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- Adenosine 5'-(trihydrogen diphosphate), monopotassium salt
- EC Number:
- 274-533-4
- EC Name:
- Adenosine 5'-(trihydrogen diphosphate), monopotassium salt
- Cas Number:
- 70285-70-0
- Molecular formula:
- C10H14KN5O10P2
- IUPAC Name:
- potassium;[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Oxidane
- Reference substance name:
- Sum of impurities from ADP, K (each < 1 %)
- IUPAC Name:
- Sum of impurities from ADP, K (each < 1 %)
- Test material form:
- solid: particulate/powder
- Details on test material:
- Batch No.: 37779100
Storage Conditions: Refrigerator (approx. 2 °C to 8 °C)
Constituent 1
impurity 1
impurity 2
- Specific details on test material used for the study:
- Lot no. 37779100
Storage: 2–8 °C, protected from light
Results and discussion
Water solubility
- Key result
- Water solubility:
- >= 242 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 23 °C
- pH:
- >= 2 - <= 3
- Details on results:
- Preliminary test:
0.1 g of the test item were dissolved in 0.5 ml of ultra-pure water, indicating a water solubility of 200 to 1000 g/l.
Main test:
The results are given in the table in the next section.The water solubility of Adenosine 5’-diphosphate monopotassium salt (dried) was determined accor¬ding to a modified test design based on the OECD 105 guideline. The water solubility was determined as the mean of the replicates analysed with HPLC. As this method does not ensure complete saturation of the solution, it will be given as minimum value in mass per volume of solution.The test is satisfactory if the concentrations of the three vessels do not differ by more than 15%.
Any other information on results incl. tables
HPLC determinations:
Test vessel | pH |
determined concentrations [g/l] sample 1 |
determined concentrations [g/l] sample 2 |
determined concentrations [g/l] mean |
A | 2-3 | 247 | 243 | 245 |
B | 2-3 | 242 | 242 | 242 |
C | 2-3 | 238 | 240 | 239 |
Overall mean [g/l]: Variation [%]: |
242 2.6 |
|||
Applicant's summary and conclusion
- Conclusions:
- The water solubility of Adenosine 5’-diphosphate monopotassium salt (dried) (CAS no. 70285-70-0) was determined according to a modified test design based on the OECD 105 guideline due to the high water solubility of the test item. The determined water solubility of Adenosine 5’-diphosphate monopotassium salt (dried), calculated as the mean of three test vessels, is =242 g/l at a pH of 2-3 and 23 °C.
- Executive summary:
The water solubility of Adenosine 5’-diphosphate monopotassium salt (dried) (CAS no. 70285-70-0) was determined according to a modified test design based on the OECD 105 guideline due to the high water solubility of the test item.
To this end, increasing volumes of ultra-pure water were added in a stepwise procedure, to about 1000 mg of the test item at 22 ± 2°C until complete dissolution, which occurred after addition of 3.7 ml water. The concentration of test item was subsequently determined by HPLC with UV detection.
The determined water solubility of Adenosine 5’-diphosphate monopotassium salt (dried), calculated as the mean of three test vessels, is =242 g/l at a pH of 2-3 and 23 °C.
The validity criterion was fulfilled.
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