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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 November 2019 - 19 December 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reaction mass of 1,10-decanediol dimethacrylate (CAS 6701-13-9) and 10-methacryloyl-oxy-decylphosphate
- Molecular formula:
- C18H30O4 and C14H27O6P
- IUPAC Name:
- Reaction mass of 1,10-decanediol dimethacrylate (CAS 6701-13-9) and 10-methacryloyl-oxy-decylphosphate
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
Product identification number: LE-F100-0804-6, 41-8650-3115-I 4010025452
Purity: Not available
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Stored at room temperature (15-25°C) in a ventilated cabinet, away from heat, acids, bases and amine in a container tightly closed.
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Rouen system wastewater treatment plant from Rouen conurbation, 29 Rue de l'ancienne Mare, 76140 Le Grand-Quevilly. Plant treats 80000 m3 of water per day with a capacity for a population of 550000.
- Storage conditions: Stored at room temperature with air supply until test. Sludge was not fed.
- Storage length: Collected on 25 October 2019, test started on 21 November 2019 (28 days).
- Concentration of sludge: 3.28 g/L at the time of collection (info from WWTP). - Duration of test (contact time):
- ca. 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- ca. 100 mg/L
- Based on:
- test mat.
- Initial conc.:
- ca. 230 mg/L
- Based on:
- ThOD
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Standard OECD 301F test medium with a substitution of sodium phosphate anhydride (266.4 mg/L).
- Additional substrate: none
- Solubilizing agent: None. Test substance was weighed and added directly to test vessels.
- Test temperature: 22°C
- pH: 7.5
- pH adjusted: No
- Suspended solids concentration: ca. 30 mg/L
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 610 mL glass flasks closed off with a manometric cap device.
- Number of culture flasks/concentration: two
- Method used to create aerobic conditions: continuous stirring
- Measuring equipment: OXITOP OC 110 Controller
- Test performed in closed vessels due to significant volatility of test substance: Yes
- Test performed in open system: no
- Details of trap for CO2 and volatile organics if used: CO2 traps with NaOH pellets were placed in each flask.
CONTROL AND BLANK SYSTEM
- Inoculum blank: duplicate
- Abiotic sterile control: one flask with test media, test item, and sterilizing agent (mercuric chloride, 0.04 g/L) as biocide
- Toxicity control: one flask with inoculum, test item and reference item (100 mg/L).
Reference substance
- Reference substance:
- benzoic acid, sodium salt
- Remarks:
- 100 mg/L
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 77 - ca. 80
- Sampling time:
- 28 d
- Details on results:
- Oxygen ulitlization in the inoculum blanks were 12 and 13 mg/L by day 28
Detailed results on oxygen utilization of test substance are provided in Table 1 and are graphically depicted in the illustration.
Detailed results on oxygen utilization by the reference substance and in the toxicity control are provided in Table 2.
Detailed results on oxygen utilization in the abiotic control are provided in Table 2. The abiotic control showed showed no oxygen utilization throughout the experiment.
The reference substance was 85.4% degraded by day 7 and 92.7% degraded by day 14 (Table 2). Biodegradation in the toxicity control (Table 2) was 58.2% by day 7 and 71.9% by day 14. Therefore, MDP is not toxic to activated sludge.
Any other information on results incl. tables
Table 1. Percent of biodegradation for the test substance
Time (days) |
Test item solution 1 |
Test item solution 2 |
Absolute difference |
0 |
0.0 |
0.0 |
- |
1 |
2.5 |
0.0 |
2.5 |
2 |
2.0 |
0.4 |
1.6 |
3 |
11.9 |
16.4 |
4.5 |
4 |
18.5 |
22.3 |
3.8 |
5 |
23.4 |
27.3 |
3.9 |
7 |
31.3 |
36.2 |
4.9 |
10 |
41.9 |
50.4 |
8.5 |
14 |
52.3 |
60.2 |
7.8 |
21 |
66.1 |
72.9 |
6.8 |
28 |
76.9 |
80.4 |
3.6 |
Table 2.Percent of biodegradation in control conditions
Time (days) |
Reference control |
Toxicity control |
Abiotic control |
0 |
0.0 |
0.0 |
0 |
1 |
5.60 |
0.50 |
< 0 |
2 |
56.7 |
28.9 |
< 0 |
3 |
72.3 |
41.0 |
< 0 |
4 |
79.5 |
48.8 |
< 0 |
5 |
78.9 |
52.7 |
< 0 |
7 |
85.4 |
58.2 |
< 0 |
10 |
89.7 |
64.4 |
< 0 |
14 |
92.7 |
71.9 |
< 0 |
21 |
95.0 |
81.6 |
< 0 |
28 |
97.4 |
86.2 |
< 0 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- difference in test substance degradation <20% (2.1%), ref substance degradation >60% by day 14 (day 3), toxicity control degradation >25% by day 14 (71.9%), oxygen uptake by inoculum blanks <60 mg/L in 28 days (12-13 mg/L), pH within range 6-8.5 (pH 7.5).
- Interpretation of results:
- readily biodegradable
- Conclusions:
- MDP was 77-80% biodegraded in a 28-day OECD 301F test.
- Executive summary:
Ready biodegradability of MDP was assessed according to OECD 301F. Duplicate flasks were used for blanks and the test substance, with single flasks for reference substance (sodium benzoate), toxicity control, and abiotic (mercuric chloride-killed) samples. The reference substance was degraded adequately by day 3. The test substance was biodegraded (77-80%) by day 28. Degradation was >10% on day 3 but did not exceed 60% by day 13, thus failing the 10-day window criteria. However, the test material a multiconstituent substance consisting of methacrylate and/or phosphate esters of 1,10-decanediol. The differing constituents are expected to have similar although not necessarily identical availability and degradation profiles. As such, the 10-day window concept is not directly applicable to this test.. The toxicity control was biodegraded 71.9% by day 14 and 86.2% by day 28. The test was conducted according to internationally accept guidelines and is GLP compliant. It is reliable without restrictions and is suitable for Risk Assessment, Classification & Labelling, and PBT Analysis.
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