Cobalt Nickel Manganese Oxide

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Automatic calculation with MeClas tool

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other: software

Title:

Unnamed

Year:

2014

Materials and methods

Principles of method if other than guideline:

Aquatic toxicity of pNMC oxide was determined by classifying based on Mixture rules from EU CLP (Tier 2 = additivity of soluble components (T/Dp data) to derive Hazard class) and back calculation to the corresponding EC10/NOEC range

Test material

Test material information

impurity 1

Reference substance name:

Total unspecified impurities

IUPAC Name:

Total unspecified impurities

Constituent 1

Reference substance name:

Cobalt Nickel Manganese Oxide

Cas Number:

37348-84-8

Molecular formula:

Ni1-x-yMnxCoyOz with Me=Ni+Mn+Co=1 and Ni/Me= 0.45-0.98 Mn/Me= 0.01-0.35 Co/Me= 0.01-0.35 O/Me= 1.00-1.33

IUPAC Name:

Cobalt Nickel Manganese Oxide

Test material form:

solid

Specific details on test material used for the study:

Generic composition, using the typical or maximum concentration for each elemental consituent.

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

<= 0.01 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

other: most sensitive species

Remarks on result:

other: worst-case composition

Effect concentrations 2

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

> 0.01 - <= 0.1 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

other: most sensitive species

Remarks on result:

other: typical composition

Any other information on results incl. tables

According to MeClas, the typical substance composition is classified as Aq.Chronic Cat.2 to the environment.

According to MeClas, the worst-case substance composition is classified as Aq.Chronic Cat.1 to the environment.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

Good quality estimate of the EC10/NOEC of pNMC oxide - typical and worst-case composition.
The typical substance composition is classified as Aq.Chronic Cat.2 to the environment resulting in a EC10/NOEC between 0.01 and 0.1 mg/L.
The worst-case substance composition is classified as Aq.Chronic Cat.1 to the environment resulting in a EC10/NOEC <= 0.01 mg/L.

Executive summary:

The study provided a conservative estimate of the effect concentration, derived on basis of the classification outcome (mixture toxicity rules) from a generic pNMC oxide sample of the substance using dissolution data that were generated with pNMC oxide-samples. 

 

Validity of the model used:

1. Defined endpoint: the endpoint is a REACH compliant defined endpoint

2. Unambiguous algorithm: EU CLP guidance based summation formula to determine classification, followed by back-calculation to related hazard criteria

3. Applicability domain: applicable to classify complex metal containing materials. 

4. Mechanistic interpretation - metal species: the tool translates the elemental composition into a soluble composition relevant for classification.