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EC number: 856-663-9 | CAS number: 2400970-89-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 September 2020 thru 14 October 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- up-and-down procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Carbamodithioic acid, bis(mixed 2-ethylhexyl and 2-methylbutyl and pentyl) derivs., antimony (3+) salts
- Molecular formula:
- C33H66N3S6Sb to C51H102N3S6Sb
- IUPAC Name:
- Carbamodithioic acid, bis(mixed 2-ethylhexyl and 2-methylbutyl and pentyl) derivs., antimony (3+) salts
- Test material form:
- liquid: viscous
Constituent 1
- Specific details on test material used for the study:
- PYSICAL DESCRIPTION: Highly viscous amber liquid.
PURITY: >99%
SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material: WT05-19
- Expiration date of the lot/batch: not applicable
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temp.
- Stability under storage conditions: stable for the duration of testing.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Received from Charles River Laboratories on September 10, 2020
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: Young adult (8-9 weeks)
- Weight at study initiation: 175.1 - 208.1 grams
- Fasting period before study: Yes, overnight
- Housing: In caging which conforms to the size recommendations in the most recent Guide for the Care and Use of Laboratory Animals (Natl. Res. Council, 2011)
- Diet (e.g. ad libitum): Envigo Teklad Global 16% Protein Rodent Diet® #2016. The diet was available ad libitum, except during fasting
- Water (e.g. ad libitum): Filtered tap water was supplied ad libitum
- Acclimation period: 7-20 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 - 23
- Humidity (%): 51 - 56
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light): 12 hours
IN-LIFE DATES: From: To: September 17 - October 14, 2020
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- Limit Dose: 2000 mg/kg-bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Days 0, 7, and 14
- Necropsy of survivors performed: yes
- Clinical signs including body weight: 30 min post-dosing, then each hour for several hours, then daily for 14 days
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: No - Statistics:
- Statistical analysis was limited to the calculation of the mean density value for dosing.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed throughout the study.
- Clinical signs:
- other: Normal; all animals active and healthy throughout the study.
- Gross pathology:
- Normal
Any other information on results incl. tables
Animal No. |
Sex |
Dose Level (mg/kg) |
Body Weight (g) |
Dose |
||
Initial |
Day 7 |
Day 14 |
mL |
|||
3101 |
F |
2000 |
175.1 |
205.4 |
227.2 |
0.72 |
3102 |
F |
185.3 |
200.6 |
205.1 |
0.76 |
|
3103 |
F |
199.1 |
216.8 |
244.8 |
0.81 |
|
3104 |
F |
200.7 |
230.6 |
244.2 |
0.82 |
|
3105 |
F |
208.1 |
241.7 |
256.7 |
0.85 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The Oral LD50 for the test substance is >2000 mg/kg-bw.
- Executive summary:
In an OECD 425 Guideline study conducted under GLP conditions using a limit dose of 2000 mg/kg-bw, no mortalities, changes in body-weight gain, clinical signs of toxicity, or abnormal findings in gross pathology were observed. Therefore, it can be concluded that the oral LD50 for the test substance is > 2000 mg/kg-bw.
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