Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 951-761-9 | CAS number: 55722-64-0
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23-07-2019 to 13-08-2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Guideline study performed under GLP. All relevant validity criteria were met.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- - Physical state: Liquid
- Storage condition of test material: In refrigerator (2-8°C) protected from light container flushed with nitrogen
- Other: colourless liquid - Melting / freezing pt.:
- ca. -11.5 °C
- Atm. press.:
- ca. 1 010 hPa
- Decomposition:
- no
- Sublimation:
- no
- Remarks on result:
- other: mean melting point (n = 2)
- Conclusions:
- The melting temperature was -11.5°C (or 261.65K).
- Executive summary:
The melting temperature was determined according to EU Method A.1 and OECD TG 102 using the Differential Scanning Calorimetry method under GLP. The guideline defines the melting temperature as: the temperature at which the phase transition from solid to liquid state occurs at atmospheric pressure and this temperature ideally corresponds to the freezing temperature. During DSC cooling an exothermic effect was observed between -20°C and -40°C, due to crystallization of the test item. The melting temperature was determined to be -11.5°C (or 261.65K).
Reference
Main study
- Experiment 1: During cooling, an exothermic effect between -20°C and -40°C was observed, which was due to crystallization of the test item. During heating, an endothermic effect between -25°C and 0°C was observed, followed by another endothermic effect between 200°C and 300°C. The extrapolated onset temperature of the second effect was 273.622°C.
- Experiment 2: Was conducted to examine the second endothermic effect by using a higher heating rate of 50°C/minute. The first endothermic peak shifted to higher temperatures, whilst the second did not, demonstrating that evaporation of the test substance was the reason for the endothermic effect. Since a higher heating rate was used, the extrapolated onset temperature of the second endothermic effect was not used in the calculation of the boiling point.
- Experiment 3: Was conducted to further examine the boiling temperature of the test item in duplicate. An endothermic peak was observed. The extrapolated onset of the evaporation peak was 263.995°C. The difference in extrapolated onset between experiment 1 and 3 was >1°C, therefore the test item may have evaporated before boiling due to a lower sample amount.
- Experiment 4: Was conducted to further examine the boiling temperature of the test item as a duplicate of experiment 3. The experiment was conducted under the same conditions as experiment 4, but with a higher sample amount. The extrapolated onset of the boiling peak was 274.326°C.
The melting temperature was determined as the mean melting temperature of Experiment 1 (-11.223°C) and Experiment 2 (-11.734°C).
Description of key information
Mp: -11.5 °C ( or 261.65 K) at 1 atmosphere, OECD TG 102 - DSC Method, 2019
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- -11.5 °C
Additional information
Key study : EU Method A.1, 2019 : The melting temperature was determined according to EU Method A.1 and OECD TG 102 using the Differential Scanning Calorimetry method under GLP. The guideline defines the melting temperature as: the temperature at which the phase transition from solid to liquid state occurs at atmospheric pressure and this temperature ideally corresponds to the freezing temperature. During DSC cooling an exothermic effect was observed between -20°C and -40°C, due to crystallization of the test item. The melting temperature was determined to be -11.5°C (or 261.65K).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
