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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 Oct - 11 Nov 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- yes
- Remarks:
- 20 °C instead of 22 °C
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Deviations:
- yes
- Remarks:
- 20 °C instead of 22 °C
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Collected from a municipal wastewater treatment plant in Usserød, Denmark.
- Laboratory culture: no
- Pretreatment: The activated sludge was stabilised under continuous aeration for a period of 2 d in order to reduce the content of easily degradable carbon.
- Concentration of sludge: 28.5 mg suspended solids (dry weight)/L - Duration of test (contact time):
- 28 d
- Initial conc.:
- 22 mg/L
- Based on:
- test mat.
- Initial conc.:
- 50.7 mg/L
- Based on:
- ThOD/L
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to guideline
- Test temperature: 19.8 ± 0.0 °C
- pH: 7.6 (test start); 7.5 - 7.6 (test end)
- pH adjusted: no
- Suspended solids concentration: 28.5 mg/L (dw)
TEST SYSTEM
- Culturing apparatus: WTW OxiTop® Control System (770 mL test volume)
- Number of culture flasks/concentration: 4
- Measuring equipment: WTW OxiTop® Control System
- Test performed in closed vessels due to significant volatility of test substance: no
SAMPLING
- Sampling frequency: continuously
- Sampling method: The OxiTop® Control system automatically determines the oxygen consumption in the test bottles.
- Sterility check if applicable: no
- Sample storage before analysis: not applicable
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes, 4 bottles
- Abiotic sterile control: no
- Toxicity control: yes, 4 bottles (containing approx. 22 mg/L test item and 20 mg/L of the reference substance)
- Other: Reference substance: yes, 4 bottles - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (O2 consumption)
- Value:
- 81
- St. dev.:
- 3
- Sampling time:
- 28 d
- Details on results:
- At the end of the 10-day window (from day 3 to day 13) a biodegradation of 65 ± 4% was measured.
- Results with reference substance:
- The reference substance was degraded to 78 ± 2% of ThOD after 14 d and 85 ± 5% of ThOD after 28 d.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to analogue justification document provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Parameter:
- % degradation (O2 consumption)
- Value:
- 81
- St. dev.:
- 3
- Sampling time:
- 28 d
- Interpretation of results:
- readily biodegradable
Referenceopen allclose all
The toxicity control attained 70% degradation after 14 d. Thus, the substance is not considered to be inhibitory to the inoculum.
Table 1: Degradation of the test substance during the test (average of four replicates)
Time [d] |
Average degradation (BOD% of ThOD) |
1 |
3.1 |
2 |
7.2 |
3 |
22.0 |
4 |
30.0 |
5 |
35.4 |
6 |
41.0301F |
7 |
46.2 |
8 |
51.6 |
9 |
55.6 |
10 |
58.4 |
11 |
60.5 |
12 |
62.0 |
13 |
64.7 |
14 |
66.3 |
15 |
67.9 |
16 |
70.8 |
17 |
71.3 |
18 |
71.7 |
19 |
73.7 |
20 |
75.2 |
21 |
75.8 |
22 |
76.7 |
23 |
77.6 |
24 |
78.3 |
25 |
79.5 |
26 |
80.2 |
27 |
80.1 |
28 |
81.1 |
Description of key information
28-day degradation (based on O2 consumption) = 81.1% (OECD 301 F); read-across
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
No study is available in which the ready biodegradability of Glycerides, C16-18 (even numbered) mono- and di- and their citrates (EC 701-358-7) was assessed. Therefore, read-across to the structurally and chemically closely related source substance Glycerides, C16 - 18 and C18 -unsaturated mono- and di-, citrates (CAS 91052-16-3) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, section 1.5 in order to fulfill the data requirements. The source substance is characterized by similar physico-chemical parameters and is therefore considered suitable representative for the assessment of the ready biodegradability of the target substance. A read-across justification is provided in IUCLID section 13.
This GLP study was conducted according to OECD guideline 301 F and EU method C.4 -D to test for the ready biodegradability of Glycerides, C16 - 18 and C18 -unsaturated mono- and di-, citrates. Activated sewage sluge from a municipal sewage treatment plant, treating domestic sewage, was incubated under aerobic conditions for 28 days at 19.8 °C with 22 mg/L of the test item and the oxygen consumption was measured daily. A degradation of 81% of the test item was observed after 28 days. Therefore, the substance was classified as readily biodegradable.
Based on the available result from a structurally related read-across substance (in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5), it can be concluded that the target substance Glycerides, C16-18 (even numbered) mono- and di- and their citrates is readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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