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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1941-02-20
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1941
Report date:
1941

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
The test item was administered gastrically with the aid of a suitable metal tube to 132 rats, in doses from 1.05 to 19.95 g/kg bw.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Propane-1,3-diol
EC Number:
207-997-3
EC Name:
Propane-1,3-diol
Cas Number:
504-63-2
Molecular formula:
C3H8O2
IUPAC Name:
propane-1,3-diol

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
1050, 2100, 3150, 4200, 5250, 6300, 7350, 8400, 9450, 10500, 11550, 12600, 13650, 14700, 15750, 16800, 17850, 18900, 19950 mg/kg bw
No. of animals per sex per dose:
At least 5 rats were used for each dose.
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
discriminating dose
Effect level:
9 450 mg/kg bw
Based on:
test mat.
Mortality:
The mortality was found to be 100 % for doses of 18.9 and 19.95 g/kg bw. The mortality varied from 10 to 64 % for doses from 11.55 to 17.85 g/kg bw. No rats died for doses from 1.05 to 9.45 g/kg bw.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The oral non lethal dose was found to be 9.45 g/kg bw.
Executive summary:

In an acute oral toxicity study the test item was administered gastrically with the aid of a suitable metal tube to 132 rats, in doses from 1050 to 19950 mg/kg bw. The mortality was found to be 100 % for doses of 18900 and 19950 mg/kg bw. The mortality varied from 10 to 64 % for doses from 11550 to 17850 mg/kg bw. No rats died for doses from 1050 to 9450 mg/kg bw.

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