3-hydroxypropyl octanoate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1941-02-20

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1941

Report date:

1941

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

The test item was administered gastrically with the aid of a suitable metal tube to 132 rats, in doses from 1.05 to 19.95 g/kg bw.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propane-1,3-diol

EC Number:

207-997-3

EC Name:

Propane-1,3-diol

Cas Number:

504-63-2

Molecular formula:

C3H8O2

IUPAC Name:

propane-1,3-diol

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

1050, 2100, 3150, 4200, 5250, 6300, 7350, 8400, 9450, 10500, 11550, 12600, 13650, 14700, 15750, 16800, 17850, 18900, 19950 mg/kg bw

No. of animals per sex per dose:

At least 5 rats were used for each dose.

Control animals:

not specified

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

discriminating dose

Effect level:

9 450 mg/kg bw

Based on:

test mat.

Mortality:

The mortality was found to be 100 % for doses of 18.9 and 19.95 g/kg bw. The mortality varied from 10 to 64 % for doses from 11.55 to 17.85 g/kg bw. No rats died for doses from 1.05 to 9.45 g/kg bw.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The oral non lethal dose was found to be 9.45 g/kg bw.

Executive summary:

In an acute oral toxicity study the test item was administered gastrically with the aid of a suitable metal tube to 132 rats, in doses from 1050 to 19950 mg/kg bw. The mortality was found to be 100 % for doses of 18900 and 19950 mg/kg bw. The mortality varied from 10 to 64 % for doses from 11550 to 17850 mg/kg bw. No rats died for doses from 1050 to 9450 mg/kg bw.