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EC number: 701-337-2 | CAS number: -
Preliminary dermal absorption study was performed in 5 rats that were exposed dermally to a 14C-RDP formulation in PEG 400 or a neat 14C-RDP solution for <15 minutes or 6 hours. Urine and faeces were collected and were analysed for radioactivity as well as the excised skin test site and the residual carcass. A post-dose period of 24 hours was chosen for two of the rats.
Total recovery was within 100 +/- 10% of the applied dose for all animals. Relative dermal absorption of RDP into the systemic circulation is similar, whether administered as neat material or as a formulation in PEG 400. Within 6 hours, approximately 17% of the dermally applied dose is absorbed in the systemic circulation. After 30 hours excretion by urine and faeces is apparent, but the largest amount of the dose is still present in the body.
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