Registration Dossier
Registration Dossier
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EC number: 411-290-7 | CAS number: 131538-00-6 MR-7 B; MR-8 B2; MR-S2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Assessed after consultation with the relevant Authority. Data migrated from NONS (67/548/EEC notification) files provided by Authority contained insufficient information.
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 471 and 472
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- GLP compliance:
- yes
- Remarks:
- No further information was provided in the SNIF file.
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,3-bis((2-mercaptoethyl)thio)-1-propanethiol
- EC Number:
- 411-290-7
- EC Name:
- 2,3-bis((2-mercaptoethyl)thio)-1-propanethiol
- Cas Number:
- 131538-00-6
- Molecular formula:
- C7 H16 S5
- IUPAC Name:
- 2,3-bis[(2-sulfanylethyl)sulfanyl]propane-1-thiol
- Reference substance name:
- 2,3-bis((2-mercaptoethyl)thio)propanethiol
- IUPAC Name:
- 2,3-bis((2-mercaptoethyl)thio)propanethiol
- Details on test material:
- - Analytical purity: no data
Constituent 1
Constituent 2
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: S. typhimurium TA98, TA100, TA1535, TA1537, and E. coli WP2 uvrA
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9-mix
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 50-5000 ¿g/plate.
Concentration range in the main test (without metabolic activation): 50-5000 ¿g/plate. - Vehicle / solvent:
- Solvent: DMSO
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- yes
- Remarks:
- DMSO
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
Results and discussion
Test results
- Species / strain:
- other: as specified above
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- 5000 µg/plate
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- Observations: no increase in the number of revertant colonies.
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'. Remarks: preliminary test and main test
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
According to DSD 67/548/EEC, the substance is not classified as mutagenic.
According to Regulation (EC) No 1272/2008, the substance is not classified as mutagenic.
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