Registration Dossier
Registration Dossier
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EC number: 411-290-7 | CAS number: 131538-00-6 MR-7 B; MR-8 B2; MR-S2
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Assessed after consultation with the relevant Authority. Data migrated from NONS (67/548/EEC notification) files provided by Authority contained insufficient information.
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Guidelines for Chemical Substances Control Law of Japan (1986)
- GLP compliance:
- yes
- Remarks:
- No further information was provided in the SNIF file.
- Limit test:
- no
Test material
- Reference substance name:
- 2,3-bis((2-mercaptoethyl)thio)-1-propanethiol
- EC Number:
- 411-290-7
- EC Name:
- 2,3-bis((2-mercaptoethyl)thio)-1-propanethiol
- Cas Number:
- 131538-00-6
- Molecular formula:
- C7 H16 S5
- IUPAC Name:
- 2,3-bis[(2-sulfanylethyl)sulfanyl]propane-1-thiol
- Details on test material:
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD(R)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- corn oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Test duration: 28 days, including an unspecified recovery period.
- Frequency of treatment:
- Dosing regime: 7 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 10, 50, 200 mg/kg bw/day
Basis:
no data
- No. of animals per sex per dose:
- Control: 5
10 mg/kg bw/day: 5
50 mg/kg bw/day: 5
200 mg/kg bw/day: 10 - Control animals:
- yes
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Haematological findings:
- effects observed, treatment-related
- Gross pathological findings:
- effects observed, treatment-related
- Details on results:
- FOOD EFFICIENCY
Poor food efficiency during exposure in the 200 mg/kg bw/day groups. During the post-exposure period the food efficiency was normal.
HAEMATOLOGY
Males in the 200 mg/kg bw/d group had a slightly increased erythrocyte level. Irregularities in the blood values of male and female animals were
observed. The prothrombin time was longer in the 200 mg/kg bw/d dose groups and in males dosed with 50 mg/kg bw/d.
GROSS PATHOLOGY
Increased liver weight in animals dosed with 200 mg/kg bw/d.
HISTOPATHOLOGY:
No deviations were reported.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day (nominal)
- Based on:
- not specified
- Sex:
- male/female
- Basis for effect level:
- other: Original NCD unit is mg/kg/day
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
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