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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 1995-12-20 to 1996-02-23
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
GLP study in accordance with recognised test guideline but: Lot/batch No.: not stated Expiration date of the lot/batch: not stated NOTE: study deemed acceptable because spectral data for test item are available, covering before and after the test period - see section 1.4 Analytical Information.
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Specific details on test material used for the study:
Batch No.: + 19951208
Key result
Water solubility:
0.74 mg/L
Conc. based on:
other: a carbon content for the test material
Incubation duration:
>= 1 - <= 3 d
Temp.:
20 °C
pH:
>= 7.05 - <= 7.62

Table 1 - Calibration of the O and I Model 700 TOC Analyser

  Sample TOC (mg/L)  
UHP control 1  0.31 
UHP control 2  0.16 
UHP control 3  0.08 
UHP control 4  0.07 
UHP control 5  0.05 (mean = 0.13 ) 
Reagent blank1  0.40 
Reagent blank 2  0.47 
Reagent blank 3  0.36 
Reagent blank 4  0.41 
Reagent blank 5  0.35 (mean = 0.40) 
Standard 1  20.0 
Standard 2  19.7 
Standard 3  19.8 
Standard 4  19.8 
Standard 5  20.0 (mean = 19.9) 

UHP = ultra-high purity water

TOC = total dissolved organic carbon

Table 2 - Total dissolved organic carbon analysis of water solubility samples for test item at 20ºC

Days shaken at 30ºC  Days equilibrated at 20ºC  TOC (mg/l)  Mean TOC (mg/l)  pH 
Sample          
1A  0.50, 0.47, 0.52  0.50  7.05 
1B  0.41, 0.43, 0.44  0.43  7.10 
2A  0.38, 0.38, 0.35  0.37  7.46 
2B  0.63, 0.59, 0.59  0.61  7.59 
3A  0.53, 0.51, 0.54,   0.53  7.61 
3B  0.91, 0.88, 0.93  0.90  7.62 

Overall mean sample TOC = 0.56 mg/L

Table 2 presents a summary of the results of the total dissolved organic carbon analysis for test item and shows a mean value of 0.56 mg/L. This is equivalent to a test item concentration of 0.74 mg/L, based on a carbon content for the test material of 75% w/w (the relative ratios of components 1,2 and 3 (see Section 3) are 100:60:40). As values of the same order were found in control samples, this is considered to be an upper estimate of water solubility.

Conclusions:
The solubility determined by TOC analyser is 0.74 mg/L at 20ºC.
Executive summary:

Water solubility was determined in accordance with EEC Method A6 and OECD method 105 using the flask shake method.

The solubility determined by TOC analyser is 0.74 mg/L at 20ºC.

Description of key information

Water solubility was determined in accordance with EEC Method A6 and OECD method 105 using the flask shake method.

The solubility determined by TOC analyser is 0.74 mg/L at 20ºC.

Key value for chemical safety assessment

Water solubility:
0.74 mg/L
at the temperature of:
20 °C

Additional information