4-amino-2-methylpyrimidine-5-methylamine

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

30 June 2010 - 22 November 2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2010

Report date:

2010

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

GLP compliance:

yes

Type of method:

effusion method: by loss of weight or by trapping vaporisate

Test material

Test material information

Constituent 1

Reference substance name:

4-amino-2-methylpyrimidine-5-methylamine

EC Number:

202-384-7

EC Name:

4-amino-2-methylpyrimidine-5-methylamine

Cas Number:

95-02-3

Molecular formula:

C6H10N4

IUPAC Name:

5-(aminomethyl)-2-methylpyrimidin-4-amine

Details on test material:

- Name of test material (as cited in study report): Grewe-diamin
- Physical state: solid

Results and discussion

Vapour pressure

Vapour pressure 1

Temp.:

20 °C

Vapour pressure:

0.012 Pa

Vapour pressure 2

Temp.:

25 °C

Vapour pressure:

0.019 Pa

Any other information on results incl. tables

DISCUSSION

All measured values show good reproducibility, giving relative standard deviations of less than 20% at temperatures from 45°C and above, and good correlation. The test item consists of a single substance with 81% purity. Therefore, the measurement data were examined for signs of artefacts originating from impurities with higher vapour pressure. Additionally, at the inspection of the Knudsen cells after heating to 150°C, only brown remnants were found, which should be taken as sign for decomposition. (Unfortunately, inspection was not made after concluding the experiment at 90°C (brown glass cells are used).) Therefore, a second evaluation was made using only experiments 2 - 4 for calculating linear regression. This resulted in a correlation coefficient r of 0.9999 and vapour pressures at 20 resp. 25°C of 1.20 * 10.03 Pa and 2.62 * 10.03 Pa, respectively. The stated vapour pressures of 1.17 * 10.02 Pa and 1.87 * 10.02 Pa represent a worst case scenario. The result of the test can be considered valid.

Applicant's summary and conclusion

Conclusions:

For the test item Grewe-diamin, the following vapour pressures at 20°C and at 25 °c were determined:
Vapour pressure at 20°C: 1.17 * 10-02 Pa
Vapour pressure at 25°C: 1.87 * 10-02 Pa

Executive summary:

The vapour pressure of Grewe-diamin was determined following EU A.4 by the effusion method (weight loss).

Vapour pressure at five different temperatures was examined. All five temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log P. The graph 1ff vs. log P shows a straight line with a correlation coefficient of - 0.9482.

For the test item Grewe-diamin, the following vapour pressures at 20°C and at 25 °c were determined:

Vapour pressure at 20°C: 1.17 * 10-02 Pa Vapour pressure at 25°C: 1.87 * 10-02 Pa