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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1997-01-31
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: 92/69/EWG, A.6
Version / remarks:
1992
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1981
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
1 323 mg/L
Temp.:
20 °C
pH:
7.2

Table 1 Results of the water solubility of the test item at 19.5 +/- 1 °C

Stirring time
[hours]

Concentrations
analysed [g/L]*

Mean concentration

[g/L]

pH**

24

1.36 / 1.34 ***

1.35

7.2 / 7.2***

48

1.28 / 1.34 ***

1.31

7.2 / 7.3***

72

1.29 / 1.33 ***

1.31

7.2 / 7.3***

 

 

Mean: 1.32

 

*mean value of duplicate analysis

** pH values of the 1:1 (v/v) diluted water samples with 0.1 M NaCl

***Duplicate samples

Conclusions:
Water solubility of the test item was determined to be 1.32 g/L at 19.5 °C.
Executive summary:

The determination of the water solubility was based on the following guidelines:

OECD guideline for testing of chemicals no. 105: "Water solubility (column elution method - flask method)", Adopted May 12, 1981.

EEC Directive 92/69 EEC, Part A, Methods for the determination of physico-chemical properties, A.6: "Water solubility". EEC Publication no. L383, December 1992.

The flask method was used for the determination of the water solubility of the test item. The water solubility of the test item was determined to be 1.32 g/L at 19.5 ± 1.0 °C.

Description of key information

The water solubility of the test item was determined to be 1.32 g/L at 20°C and pH 7.15 (reference 4.8 -1).

Key value for chemical safety assessment

Water solubility:
1.32 g/L
at the temperature of:
20 °C

Additional information

The determination of the water solubility was based on the following guidelines:

OECD guideline for testing of chemicals no. 105: "Water solubility (column elution method - flask method)", Adopted May 12, 1981.

EEC Directive 92/69 EEC, Part A, Methods for the determination of physico-chemical properties, A.6: "Water solubility". EEC Publication no. L383, December 1992.

The flask method was used for the determination of the water solubility of the test item. The water solubility of the test item was determined to be 1.32 g/L at 19.5 ± 1.0 °C.