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EC number: 606-048-4 | CAS number: 18531-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12. 09. – 27. 09. 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was carried out in accordance with internationally valid GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- [1,1'-binaphthalene]-2,2'-diol
- EC Number:
- 606-048-4
- Cas Number:
- 18531-94-7
- Molecular formula:
- C20H14O2
- IUPAC Name:
- [1,1'-binaphthalene]-2,2'-diol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: breeding farm VELAZ s.r.o., Koleč u Kladna, Czech Republic
- Age at study initiation: 8-10 weeks at the time application
- Weight at study initiation: 149 - 178 g
- Fasting period before study: 20 h
- Housing: animal room with monitoring conditions – 3 animals of one sex in one plastic breeding cage
- Diet (e.g. ad libitum): ST 1 BERGMAN – standard pelleted diet
- Water (e.g. ad libitum): drinking tap water
- Acclimation period: 12 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3°C, permanently monitored
- Humidity relative (%): 30 – 70 %, permanently monitored
- Air changes (per hr): approximately 15 air changes per hour
- Photoperiod (hrs dark / hrs light): light period 12-hour light/12 hour dark
IN-LIFE DATES:
Animal supply: 31. 08. 2011
Experimental part of study: 12. 09. - 27. 09. 2011
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0,5% Methylcelulose in aqua pro injectione
- Details on oral exposure:
- CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: Test procedure with a starting dose of 2000 mg/kg was selected according to EU Method B.1 tris Annex 1D.
START: 2000 mg/kg – 3 females (Step No.1): no deaths ► 2000 mg/kg – 3 females (Step No. 2): no deaths ► END of study - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Time schedule of observations:
- Body weight: before application, the 8th day and before euthanasia of animals
- Mortality: daily
- Clinical examination: daily
- Pathological examination: 15th day
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The test substance administered at the dose of 2000 mg/kg caused no death of animals.
- Clinical signs:
- other: No clinical signs of intoxication were observed after application in all six animals.
- Gross pathology:
- No pathologic macroscopic changes were diagnosed during pathological examination.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the study results the value of LD50 of the test substance, (R)-(+)-1,1´-Bi-2-naphthol, (in female rats) is higher than 2000 mg/kg of body weight.
- Executive summary:
The aim of the study was to investigate acute toxic effects of the test substance, (R)-(+)-1,1´-Bi-2-naphthol, after a single oral administration to Wistar rats.
The testing was performed according to the Method B.1 tris: Acute Oral Toxicity - Acute Toxic Class Method, Council Regulation (EC) No.440/2008, published in O.J. L 142, 2008.
The test substance was administered in a single dose as suspension in vehicle (0.5% methylcelulose), given orally via gavage to groups of three female Wistar rats.
The dosing was performed sequentially in two groups of three females: group No. 1 - first step using the starting dose of 2000 mg/kg of body weight and group No. 2 - second step using the same dose.
The test substance administered at the dose of 2000 mg/kg caused no death of animals.
No clinical sign of intoxication were observed after application in all six animals.
No pathologic macroscopic changes were diagnosed during pathological examination.
According to the study results the value of LD50 of the test substance for female rats is higher than 2000 mg/kg of body weight.
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