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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2019-07-15 to 2019-08-23
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: Knudsen cell
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0 Pa
Test no.:
#3
Temp.:
50 °C
Vapour pressure:
0 Pa

The vapour pressure was measured in the temperature range of 78 to 102 °C. The measured vapour pressure values together with the measured temperatures are listed below:

 

Results of the Effusion method

No.

Temperature / °C

Vapour pressure / Pa

1

78

1.50 ×10-3

2

83

2.08 ×10-3

3

87

2.97 ×10-3

4

92

4.70 ×10-3

5

97

6.36 ×10-3

6

102

7.62 ×10-3

 

From the measured data points of the vapour pressure curve the constants A and B of the Antoine equation can be derived by regression of the data points to:

A = 9.8027

B = -4438.32

C = 273.15.

The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation EC No. 440/2008 Method A.4.Vapour Pressureand OECD Test Guideline 104 (2006).

 

Calculated vapour pressure values for 20, 25 and 50 °C

Temperature / °C

Vapour pressure / Pa

20

4.6 ×10-6

25

8.3 ×10-6

50

1.2 ×10-4

 

Conclusions:
The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C to be 4.6E-6 Pa, 8.3E-6 Pa and 1.2E-4 Pa, respectively.
Executive summary:

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure was measured in the temperature range of 78 to 102 °C using the effusion method (vapour pressure balance). All measured values showed good reproducibility, giving relative standard deviations of less than 25 %, and good correlation. Therefore, the result of the test according to the guideline criteria was considered to be valid. The vapour pressure was calculated using the linear regression equation of the Log P versus 1/T function. The vapour pressure was calculated for the temperatures 20, 25 and 50 °C to be 4.6E-6 Pa, 8.3E-6 Pa and 1.2E-4 Pa, respectively.

Description of key information

The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C to be 4.6E-6 Pa, 8.3E-6 Pa and 1.2E-4 Pa, respectively (reference 4.6 -1).

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item (reference 4.6 -1). The vapour pressure was measured in the temperature range of 78 to 102 °C using the effusion method (vapour pressure balance). All measured values showed good reproducibility, giving relative standard deviations of less than 25 %, and good correlation. Therefore, the result of the test according to the guideline criteria was considered to be valid. The vapour pressure was calculated using the linear regression equation of the Log P versus 1/T function. The vapour pressure was calculated for the temperatures 20, 25 and 50 °C to be 4.6E-6 Pa, 8.3E-6 Pa and 1.2E-4 Pa, respectively.