Registration Dossier
Registration Dossier
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EC number: 264-709-9 | CAS number: 64157-14-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- no detailed information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted 12 May 1981
- Deviations:
- yes
- Remarks:
- no detailed information
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Hydrogen tetrakis[2,2-bis[(allyloxy)methyl]butan-1-olato-O1]bis(ditridecyl phosphito -O'')titanate(2-)
- EC Number:
- 264-709-9
- EC Name:
- Hydrogen tetrakis[2,2-bis[(allyloxy)methyl]butan-1-olato-O1]bis(ditridecyl phosphito -O'')titanate(2-)
- Cas Number:
- 64157-14-8
- Molecular formula:
- not applicable (UVCB substance)
- IUPAC Name:
- dihydrogen 2-{[(di{[bis(tridecyloxy)phosphanyl]oxido}tris({2,2-bis[(prop-2-en-1-yloxy)methyl]butyl}oxido)titaniotetrakis(ylium))oxido]methyl}-1-(prop-2-en-1-yloxy)-2-[(prop-2-en-1-yloxy)methyl]butane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- Albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 – 300 g
- Fasting period before study: 18 h
- Diet: ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 1000, 2000, 4000, 8000 and 16000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes - Statistics:
- The LD50 was determined by Litchfield Wilcoxin Method
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 600 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 200 - 6 600
- Mortality:
- 1000 mg/kg bw: 0/5 males and 0/5 females died
2000 mg/kg bw: 0/5 males and 0/5 females died
4000 mg/kg bw: 0/5 males and 0/5 females died
8000 mg/kg bw: 2/5 males and 2/5 females died
16000 mg/kg bw: 5/5 males and 5/5 females died - Gross pathology:
- Autopsy was unremarkable, major organs all appeared normal. Slight distention of stomach was noted. No signs of gross toxiciuty were observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- CLP: not classified
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