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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental start date 14 September 2018, Experimental completion date 09 November 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method

Test material

1
Chemical structure
Reference substance name:
2-bromo-6-(4-methylbenzoyl)pyridine
EC Number:
618-079-0
Cas Number:
87848-95-1
Molecular formula:
C13H10BrNO
IUPAC Name:
2-bromo-6-(4-methylbenzoyl)pyridine

Results and discussion

Water solubility
Key result
Water solubility:
>= 6 - <= 6.2 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
ca. 6.8

Any other information on results incl. tables

The detector calibration was found to be linear over the range 0 to 10 mg/L with a regression coefficient of 1.0000

The tables sbelow present a summary of the results of the test. It shows a measured solubility of 6.1 ± 0.1 mg/L.

Column flow rate 0.4 mL/minute

Sample number Solubility (mg/L) pH
0.4A 6.875 6.7
0.4B 6.680 6.8
0.4C 6.626 6.7
0.4D 6.180 6.8
0.4E 6.117 6.8
0.4F 5.938 6.8

Water solubility = 6.08 ± 0.13 mg/L (RSD = 2.1%), determined as the mean of samples D to F once an equilibrium value had been established.

Column flow rate 0.2 mL/minute

Sample number Solubility (mg/L) pH
0.2A 6.274 6.9
0.2B 6.226 6.8
0.2C 6.057 6.8
0.2D 6.040 6.9
0.2E 6.120 6.9

Acceptable mean recoveries of approximately 99 and 95% of 2-Bromo-6-(4-toluoyl)pyridine from fortified samples were achieved at the high and LOQ levels, respectively.

Applicant's summary and conclusion

Conclusions:
The water solubility of 2-Bromo-6-(4-toluoyl)pyridine was determined to be 6.1 mg/L at 20 °C.