Alkyl-[2-(alkyl-substituted-phosphinoyl)-alkyl]-phosphinic acid

Endpoint summary

Additional information

Short-term toxicity to fish

Two studies according OECD Guideline 203 are available. In one study the test item was found to cause no toxic effects to Zebrafish after 96 hours when tested with the limit concentration of 100 mg/L. The LC50 after 96 hours is > 100 mg/L. All effect levels are given based on the nominal concentration level of the test item. In the second study the results showed that under valid static test conditions, the 96 h-LC50 of the test item to Rare minnow is greater than the nominal concentration of 100 mg /L (measured concentration 93.0 mg/L), while the maximum concentration causing no mortality (96 h-LC0) is equal to the nominal concentration of 100 mg /L (measured concentration 93.0 mg/L).

 

Short term toxicity to aquatic invertebrates

Based on the nominal concentrations of the test item the 48-h EC50 for Daphnia magna was estimated to be 70.7 mg/L (95 % confidence limits: 50.0 – 100 mg/L). The NOEC after 48 h was 50.0 mg/L. The LOEC after 48 h was 100 mg/L.

The effects observed at the concentration level of 100 mg/L were caused by the low pH-values (pH below the recommended range of pH 6 – 9). This was confirmed by the pH-neutralized concentration level of 100 mg/L which caused no effects on Daphnia magna. Based on the pH-neutralized concentration the 48-h EC50 and the NOEC for Daphnia magna were > 100 mg/L.

 

Toxicity to aquatic algae and cyanobacteria

In this study the test item was found to inhibit the growth of the freshwater green alga Desmodesmus subspicatus after 72 hours with the following effect values (nominal test item concentrations). The NOEC-values for both inhibition of growth rate and yield after 72 hours were 32.0 mg/L. The LOEC-values for both inhibition of growth rate and yield after 72 hours were 100 mg/L. The EC50-values for inhibition of growth rate (ErC50) and yield (EyC50) with 95 % confidence intervals after 72 hours were 47.8 (34.5 – 78.5) and 44.2 (32.8 – 84.4) mg/L, respectively. At the highest test concentration no inhibition of the growth rate and a lower inhibition of yield was observed when tested at a pH-value of 8.04. Therefore, it is considered that the pH value has a major influence on the inhibiting effect of the test item. The pH neutralization also reflects the actually existing environmental conditions in the buffered aquatic systems. Based on the pH-neutralized concentration the NOEC-values for both the inhibition of the growth rate and the inhibition of the yield after 72 hours were < 100 mg/L. The EC50-values for the inhibition of growth rate (ErC50) and yield (EyC50) after 72 hours were > 100 mg/L and ≤ 100 mg/L. All effect levels are given based on nominal concentrations of the test item.

 

Toxicity to microorganisms

A Respiration Inhibition Test with activated sludge according to OECD Guideline No. 209 (2010) was carried out with the test itemunder static conditions with the limit concentration 1000 mg/L pH adjusted.

The NOEC of the test item is 1000 mg/L. The test substance caused no inhibiting effects on activated sludge of a municipal sewage treatment plant at the limit concentration of 1000 mg/L.