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EC number: 265-367-3 | CAS number: 65072-36-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Lithium 2-aminobenzothiazole-6-sulphonate
- EC Number:
- 265-367-3
- EC Name:
- Lithium 2-aminobenzothiazole-6-sulphonate
- Cas Number:
- 65072-36-8
- Molecular formula:
- C7H6N2O3S2.Li
- IUPAC Name:
- lithium 2-amino-1,3-benzothiazole-6-sulfonate
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Bulk Density (g/ml): 0.39
- Particle size distribution (μm): 19.6
- Water solubility: 20%
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: IR2510181
- Expiration date of the lot/batch: 25 October 2019
- Purity test date: Not specified
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At controlled room temperature (15 - 25 °C, ≤ 70% RH)
- Stability under test conditions: Not specified
- Solubility and stability of the test substance in the solvent/vehicle: soluble at 100 mg/L in dilution water (ISO medium)
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: Dissolved in ISO medium
- Preliminary purification step (if any): Not specified
- Final dilution of a dissolved solid, stock liquid or gel: 100 mg/L (nominal)
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg/L.
- Analytical measurements were performed at the start and end of the test.
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM
- Strain: 61.81 SAG
- Source: SAG - Collection of Algal Cultures, Institute of Plant Physiology, Univ. Göttingen, Germany.
- Age of inoculum: 4 days.
Study design
- Test type:
- static
- Water media type:
- other: ISO medium, reconstituted water
- Limit test:
- yes
- Total exposure duration:
- 72 h
Test conditions
- Hardness:
- The reconstituted water (ISO medium) had a total hardness of 245 mg/L (as CaCO3).
- Test temperature:
- Culture temperature was checked at the beginning of the experiment and each day thereafter in a flask filled with water, in the climatic chamber. In addition, water temperature was continuously measured (with a min/max thermometer) within the climate chamber. The temperature was 22.3-22.7°C measured in the flask and 21.0-23.5°C measured within the climate chamber.
- pH:
- The pH was checked at the beginning and at the end of the test, in the control and each concentration. The pH of the control medium was not increased by more than 1.5 units during the test. The range of the pH was 7.51 – 8.94 during the experiment.
- Nominal and measured concentrations:
- Nominal concentration: 100 mg/L.
Measured concentration (start of study): 94.9 ± 1.742 mg/L
Measured concentration (end of study): 97.3 ± 0.893 mg/L. - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass (Erlenmeyer flask)
- Type: closed
- Volume: 250 mL
- Initial cells density: 10^4 cells/mL
- Test end cells density: 50.83 x 10^4 cells/mL
- Control end cells density: 70.83 x 10^4 cells/mL
- No. of vessels per concentration (replicates): 6
- No. of vessels per control (replicates): 6
Results and discussion
Effect concentrations
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Details on results:
- The Test Item had no toxic effects on growth rate, had 27% inhibition effect on the algae biomass and 29% effect on yield at 100 mg/L (nominal); the EC50 results are higher than this level of the Test Item in the test medium.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a study in Pseudokirchneriella subcapitata, lithium 2-aminobenzothiazole-6-sulphonate was found to have an EC50 > 100 mg/L.
- Executive summary:
In an OECD guideline study, conducted to GLP, lithium 2-aminobenzothiazole-6-sulphonate was found to have an EC50 > 100 mg/L in Pseudokirchneriella subcapitata.
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