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Diss Factsheets
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EC number: 437-450-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 29 July 1999 and 15 December 1999.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- HPLC Method, Method 117 of the OECD Guidelines for Testing of Chemicals, 30 March 1989.
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- No further details specified in the study report.
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 4.11
- pH:
- 7.35
- Remarks on result:
- other: Temp not specified in the study report
- Details on results:
- Substances having a log10 Pow greater than 3 are regarded as having the potential to bioaccumulate in the environment.
APAN is estimated to have a pKa of approximately 1.6. The pH of the mobile phase (7.35) was such that the test material was tested in its unionised form. - Conclusions:
- The partition coefficient of APAN has been determined to be 1.29 x 104, log10 Pow 4.11.
- Executive summary:
Partition coefficient determined as 1.29 x 104, log10 Pow 4.11, using the HPLC method, Method 117 of the OECD Guidelines for Testing of Chemicals, 30 March 1989.
Reference
Definitive Test
Calibration
The retention time of thiourea and the reference standards
Dead time |
Retention time (mins) |
Mean retention time (mins) |
|
Injection 1 |
Injection 2 |
||
Thiourea |
2.622 |
2.417 |
2.520 |
Standard |
Retention time (mins) |
Mean retention time (mins) |
|
Injection 1 |
Injection 2 |
||
Benzene |
6.467 |
6.571 |
6.519 |
Toluene |
8.354 |
8.483 |
8.419 |
Naphthalene |
9.980 |
10.131 |
10.056 |
Phenanthrene |
16.497 |
16.721 |
16.609 |
Triphenylamine |
34.657 |
35.138 |
34.898 |
DDT |
48.156 |
48.719 |
48.438 |
The capacity factors (k) and log10 Pow value for the reference standards
Standard |
Capacity factor (k) |
Log10 k |
Log 10 Pow |
Benzene |
1.587 |
0.201 |
2.1 |
Toluene |
2.341 |
0.369 |
2.7 |
Naphthalene |
2.991 |
0.476 |
3.6 |
Phenanthrene |
5.592 |
0.748 |
4.5 |
Triphenylamine |
12.851 |
1.109 |
5.7 |
DDT |
18.225 |
1.261 |
6.2 |
Partition coefficient of sample
The retention times, capacity factors and log10 Pow values determined for the sample
Injection |
Retention time (mins) |
Capacity factor (k) |
Log10 k |
Log10 Pow |
1 |
14.826 |
4.885 |
0.689 |
4.11 |
2 |
14.768 |
4.861 |
0.687 |
4.11 |
Mean log10 Pow: 4.11
Partition coefficient: 1.29 x 104
Description of key information
Partition coefficient determined as 1.29 x 104, log10 Pow 4.11.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.11
Additional information
Partition coefficient determined as 1.29 x 104, log10 Pow 4.11, using the HPLC method, Method 117 of the OECD Guidelines for Testing of Chemicals, 30 March 1989.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.