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Diss Factsheets
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EC number: 437-450-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 May 1999 to 02 December 1999.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- No further details specified in the study report.
- Radiolabelling:
- not specified
- Analytical monitoring:
- yes
- Details on sampling:
- Aliquots of the sample solutions were taken from the flasks at various times and the pH of each solution recorded.
The concentration of the sample solution was determined by high performance liquid chromatography (HPLC). - Buffers:
- The buffer solutions were filtered through 0.2 μm membrane filters to ensure they were sterile before commencement of the test. Also these solutions were subjected to ultrasonication and degassing with nitrogen to minimise dissolved oxygen content.
Further details tableted see “Any other information” - Details on test conditions:
- Preparation of samples
Sample solutions were prepared in stoppered glass flasks at a nominal concentration of 1.50 x 10e-3 g/l in the three buffer solutions (with a 1% acetonitrile co-solvent).
The solutions were shielded from light whilst maintained at the test temperature.
Preliminary Test/Test 1
Sample solutions at pH 4, 7 and 9 were maintained at 50.0 ± 0.5 °C for a period of 120 hours. - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.002 g/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.002 g/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.002 g/L
- Number of replicates:
- Duplicate aliquots (A and B) of the test material and each sample solution.
- Positive controls:
- no
- Negative controls:
- yes
- Statistical methods:
- Not specified
- Preliminary study:
- See "Any other information" for details
- Test performance:
- The analytical method has been determined to be substance specific and of sufficient accuracy for the test material in this study.
- Transformation products:
- not specified
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Other kinetic parameters:
- Not specified
- Details on results:
- Reported in table form - see "Any other information" for details
- Results with reference substance:
- Not specified
- Validity criteria fulfilled:
- yes
- Conclusions:
- The results for all pH levels tested, 4, 7 and 9, was less than 10% hydrolysis after 5 days at 50 °C equivalent to a half-life of greater than 1 year at 25 °C.
- Executive summary:
The hydrolysis of APAN as a function of pH has been determined.
The method employed complied with that specified in Method 11 1 of the OECD Guidelines for Testing of Chemicals, 12 May 1981.
The results for all pH levels tested, 4, 7 and 9, was less than 10% hydrolysis after 5 days at 50 °C equivalent to a half-life of greater than 1 year at 25 °C.
Reference
The mean peak areas relating to the standard and sample solutions
Solution |
Mean peak area |
Standard 0.749 mg/l Standard 0.801 mg/l Initial Sample A, pH 4 Initial Sample B, pH 4 Initial Sample A, pH 7 Initial Sample B, pH 7 Initial Sample A, pH 9 Initial Sample B, pH 9 |
16.537 18.519 18.223 16.898 17.371 16.902 16.707 16.448 |
Standard 0.749 mg/l Standard 0.801 mg/l 2.4 hour Sample A, pH 4 2.4 hour Sample B, pH 4 2.4 hour Sample A, pH 7 2.4 hour Sample B, pH 7 2.4 hour Sample A, pH 9 2.4 hour Sample B, pH 9 |
15.628 18.513 17.754 17.549 17.151 17.420 15.164 15.231 |
Standard 0.749 mg/l Standard 0.801 mg/l 24 hour Sample A, pH 4 24 hour Sample B, pH 4 24 hour Sample A, pH 7 24 hour Sample B, pH 7 24 hour Sample A, pH 9 24 hour Sample B, pH 9 |
16.612 17.163 16.736 15.586 * 15.077 15.680 16.161 |
Standard 0.749 mg/l Standard 0.801 mg/l 120 hour Sample A, pH 4 120 hour Sample B, pH 4 120 hour Sample A, pH 7 120 hour Sample B, pH 7 120 hour Sample A, pH 9 120 hour Sample B, pH 9 |
15.031 15.194 14.933 14.791 14.587 15.935 14.249 13.658 |
* Not used inconsistent peak area (possible dilution error)
pH 4 at 50.0±0.5°C
Time (hours) |
0 |
2.4 |
24 |
120 |
Concentration (g/l) |
1.55 x 10-3 |
1.61 x 10-3 |
1.46 x 10-3 |
1.48 x 10-3 |
% of initial |
100 |
103 |
94 |
95 |
Less than 10% hydrolysis after 5 days at 50°C, equivalent to a half-life of greater than 1 year at 25°C
pH 7 at 50.0±0.5°C
Time (hours) |
0 |
2.4 |
24 |
120 |
Concentration (g/l) |
1.52 x 10-3 |
1.57 x 10-3 |
1.36 x 10-3 |
1.52 x 10-3 |
% of initial |
100 |
104 |
90 |
100 |
Less than 10% hydrolysis after 5 days at 50°C, equivalent to a half-life of greater than 1 year at 25°C
pH 9 at 50.0±0.5°C
Time (hours) |
0 |
2.4 |
24 |
120 |
Concentration (g/l) |
1.47 x 10-3 |
1.38 x 10-3 |
1.44 x 10-3 |
1.39 x 10-3 |
% of initial |
100 |
94 |
98 |
95 |
Less than 10% hydrolysis after 5 days at 50°C, equivalent to a half-life of greater than 1 year at 25°C
Description of key information
The hydrolysis of APAN as a function of pH has been determined in a GLP accredited laboratory study in accordance with OECD Guideline No. 111.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
The hydrolysis of APAN as a function of pH has been determined.
The results for all pH levels tested, 4, 7 and 9, was less than 10% hydrolysis after 5 days at 50 °C equivalent to a half-life of greater than 1 year at 25 °C.
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