Magnesium perchlorate

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in bacteria

Remarks:

in silico, (Q)SAR performed with OECD QSAR Toolbox, Read Across analysis

Type of information:

other: (Q)SAR from supporting substances (structural analogues or surrogates) for which an experimental result is available

Adequacy of study:

key study

Study period:

2019-03-29

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification, with an experimental result (as provided by the OECD QSAR Toolbox)

Justification for type of information:

1. SOFTWARE
OECD QSAR Toolbox v4.3.1

2. MODEL (incl. version number)
Read Across analysis

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
[Mg+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
Please refer to 'Attached justification'

5. APPLICABILITY DOMAIN
Please refer to 'Attached justification'

Data source

Reference

Reference Type:

other: estimation software

Title:

Unnamed

Year:

2019

Materials and methods

Test guideline

Guideline:

other: ECHA Guidance R.6

Principles of method if other than guideline:

- Software tool(s) used including version: OECD QSAR Toolbox v4.3.1
- Model(s) used: Read Across analysis
- Model description: see field 'Justification for non-standard information' and 'Attached justification'
- Justification of QSAR prediction: see field 'Justification for type of information' and 'Attached justification'

GLP compliance:

not specified

Remarks:

Not applicable (QSAR calculation

Type of assay:

bacterial reverse mutation assay

Test material

Test material information

Constituent 1

Reference substance name:

Magnesium perchlorate

EC Number:

233-108-3

EC Name:

Magnesium perchlorate

Cas Number:

10034-81-8

Molecular formula:

ClHO4.1/2Mg

IUPAC Name:

magnesium perchlorate

Specific details on test material used for the study:

[Mg+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O

Method

Species / strain

Species / strain / cell type:

S. typhimurium TA 1535

Results and discussion

Test results

Species / strain:

S. typhimurium TA 1535

Metabolic activation:

not applicable

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

not determined

Vehicle controls validity:

not applicable

Untreated negative controls validity:

not applicable

True negative controls validity:

not applicable

Positive controls validity:

not applicable

Remarks on result:

no mutagenic potential (based on QSAR/QSPR prediction)

Applicant's summary and conclusion

Conclusions:

The genetic toxicity of Magnesium perchlorate was predicted with OECD QSAR Toolbox v4.3.1 using experimental results of the analogue Lithium perchlorate (CAS 7791-03-9). Since the perchlorate is considered to trigger the toxicity, this approach is justified. The prediction is negative.

Predictions by the OECD QSAR Toolbox v4.3.1 with experimental result(s) of closely related perchlorate with CAS 7791-03-9 contained therein are used to address the endpoint, which is entirely appropriate to draw conclusions on the genetic toxicity of Magnesium perchlorate.

Executive summary:

The genetic toxicity of Magnesium perchlorate was predicted with OECD QSAR Toolbox v4.3.1 using experimental results of the analogue Lithium perchlorate (CAS 7791-03-9). Since the perchlorate is considered to trigger the toxicity, this approach is justified. The prediction is negative.

Predictions by the OECD QSAR Toolbox v4.3.1 with experimental result(s) of closely related perchlorate with CAS 7791-03-9 contained therein are used to address the endpoint, which is entirely appropriate to draw conclusions on the genetic toxicity of Magnesium perchlorate.