Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Reported 25May1998
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1998
Report Date:
1998

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
no
Type of method:
flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
See individual study reports for purity information and CofA where applicable
Specific details on test material used for the study:
MIP Orange 3100 (CGF-F020088/0010)

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Key result
Type:
Pow
Partition coefficient:
ca. 0.007
Temp.:
20 °C
pH:
ca. 7
Key result
Type:
log Pow
Partition coefficient:
ca. -2.13
Temp.:
20 °C
pH:
ca. 7

Applicant's summary and conclusion

Conclusions:
Three portions of the test sample of about 25 mg each were mixed with about 30 ml of n-octanol each. The n-octanol is saturated with the test substance by mixing vigorously in an ultrasonic bath. The mixture is decanted, filtered through a Millipore filter and made up to 50 ml volume in a volumetric flask, using n-octanol.

10 ml portions of the solutions are mixed with water according to OECD method no. 107.

After partition, the content of test substance is determined in the aqueous and organic layer by ion pair HPLC using UV/VIS-detection. Each sample was analyzed twice.
The test item had the following results for the partition coefficient test Pow, = 0.0073; log Pow = -2.13
Executive summary:

Three portions of the test sample of about 25 mg each were mixed with about 30 ml of n-octanol each. The n-octanol is saturated with the test substance by mixing vigorously in an ultrasonic bath. The mixture is decanted, filtered through a Millipore filter and made up to 50 ml volume in a volumetric flask, using n-octanol.

 

10 ml portions of the solutions are mixed with water according to OECD method no. 107.

 

After partition, the content of test substance is determined in the aqueous and organic layer by ion pair HPLC using UV/VIS-detection. Each sample was analyzed twice.

The test item had the following results for the partition coefficient test Pow, = 0.0073; log Pow = -2.13