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Physical & Chemical properties

Water solubility

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Endpoint:
transformation / dissolution of metals and inorganic metal compounds
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April to June 2022
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Type of test:
screening transformation/dissolution test - sparingly soluble metal compounds
Mean dissolved conc.:
> 0 - < 1.7 mg/L
Element analysed:
Manganese
Loading of aqueous phase:
100
Incubation duration:
24 h
Test conditions:
according to OECD TG 29
Details on results:
Awaiting final results from the laboratory
Conclusions:
Water solubility is <1.7mg/L
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
12 to 13 August 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
not specified
Type of method:
flask method
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Nitika Pharmaceutical Specialities Pvt. Ltd.
- Expiration date of the lot/batch: no data
- Purity test date: no data

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:
- Stability under test conditions:
- Solubility and stability of the test substance in the solvent/vehicle:
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium:

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing:
- Preliminary purification step (if any):
- Final dilution of a dissolved solid, stock liquid or gel:
- Final preparation of a solid:

FORM AS APPLIED IN THE TEST (if different from that of starting material)

TYPE OF BIOCIDE/PESTICIDE FORMULATION (if applicable)

OTHER SPECIFICS:
- measurement of pH, osmolality, and precipitate in the culture medium to which the test chemical is added:
- other information:
Key result
Water solubility:
< 0.17 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
7.54
Details on results:
The water solubility was estimated as < 0.17 mg/L. This concentration is below the limit of detection of the analytical method available. As a result software estimation was applied.

The prediction software uses SMILES input to calculate the Water Solubility.
In accordance with test guidance the water solubility was estimated using WSKOW v1.42 as: Water Solubility at 25°C = 1.363 x 10-11 mg.L-1 (estimated)


Conclusions:
The prediction software uses SMILES input to calculate the Water Solubility.
In accordance with test guidance the water solubility was estimated using WSKOW v1.42 as: Water Solubility at 25°C = 1.363 x 10-11 mg.L-1 (estimated)

Description of key information

The prediction software uses SMILES input to calculate the Water Solubility.

In accordance with test guidance the water solubility was estimated using WSKOW v1.42 as:

Water Solubility at 25°C = 1.363 x 10-11mg.L-1(estimated)

Key value for chemical safety assessment

Water solubility:
0.17 mg/L
at the temperature of:
20 °C

Additional information