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EC number: 701-302-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Meets generally accepted scientific standards with acceptable restrictions. This study is conducted on an analogue substance. Read-across is justified on the following basis: In aqueous solutions at physiological and acidic pH, low concentrations of simple inorganic borates such as boric acid, disodium tetraborate decahydrate, disodium tetraborate pentahydrate, boric oxide and disodium octaborate tetrahydrate will predominantly exist as undissociated boric acid. At about pH 10 the metaborate anion (B(OH)4-) becomes the main species in solution (WHO, 1998). This leads to the conclusion that the main species in the plasma of mammals and in the environment is un-dissociated boric acid. Since other borates dissociate to form boric acid in aqueous solutions, they too can be considered to exist as un-dissociated boric acid under the same conditions. For comparative purposes, exposures to borates are often expressed in terms of boron (B) equivalents based on the fraction of boron in the source substance on a molecular weight basis. Some studies express dose in terms of B, whereas other studies express the dose in units of boric acid. Since the systemic effects and some of the local effects can be traced back to boric acid, results from one substance can be transferred to also evaluate the another substance on the basis of boron equivalents. Therefore data obtained from studies with these borates can be read across in the human health assessment for each individual substance. Conversion factors are given in the table below. Conversion factor for equivalent dose of B Boric acid H3BO3 0.175 Boric Oxide B2O3 0.311 Disodium tetraborate anhydrous Na2B4O7 0.215 Disodium tetraborate pentahydrate Na2B4O7•5H2O 0.148 Disodium tetraborate decahydrate Na2B4O7•10H2O 0.113 Disodium octaborate tetrahydrate Na2B8O13•4H2O 0.210 Sodium metaborate (anhydrous) NaBO2 0.1643 Sodium metaborate (dihydrate) NaBO2•2H2O 0.1062 Sodium metaborate (tetrahydrate) NaBO2•4H2O 0.0784 Sodium pentaborate (anhydrous) NaB5O8 0.2636 Sodium pentaborate (pentahydrate) NaB5O8∙5H2O 0.1832 References: WHO. Guidelines for drinking-water quality, Addendum to Volume 1, 1998.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of single and repeated exposure to biocidal active substances on the barrier function of the skin in vitro.
- Author:
- Buist HE, van de Sandt JJM, van Burgsteden JA & de Heer C
- Year:
- 2 005
- Bibliographic source:
- Regulatory Toxicology and Pharmacology 43: 76 – 84.
Materials and methods
- Type of study / information:
- The influence of repeated and single exposure to boric acid on the skin barrier was investigated in vitro using static diffusion cells from cryopreserved human abdominal skin from 7 female donors.
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Deviations:
- not specified
- Principles of method if other than guideline:
- The influence of repeated and single exposure to boric acid on the skin barrier was investigated in vitro using static diffusion cells from cryopreserved human abdominal skin from 7 female donors. The dermis was partially removed using forceps and scissors and the average skin thickness was 0.702 ± 0.062 mm. The skin preparations were exposed to 10 μL/cm2 of a solution of boric acid for 4 h (single exposure) starting 4 h after the onset of the experiment or for 3 times 4 h (repeated exposure, starting at 0, 24 and 48 h respectively). The test material was tested at 3 concentrations, representing the range of concentration in which it may be present in products. Each exposure period was finished by washing off the test substance using 4 cotton swabs humidified with 3 % Teepol solution and subsequently drying the skin preparations using 2 dry cotton swabs. The same procedure was applied ot the control skin. All skins were washed three times in order to control fora a possible effect of the washing procedure on skin permeability. For each concentration the single and multiple dosing experiments were always performed with skin from the same donor wiht controls performed in parallel. The integrity of the skin preparations were assessed prior to the start of the experiment by determining the permeability coefficient (Kp) of tritiated water. In addition [14C]propoxur was used as a marker of skin permeability by applying at the end of the exposure period. During the following 3 h samples of receptor fluid were collected for every hour and assayed for tritated water and 14C-radioactivity by liquid scintillation counting. Fluid was replaced by adding fresh receptor fluid after each sampling and the amound of radiolabelled marker molecules that had penetrated the skin was plotted against time.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Boric acid
- EC Number:
- 233-139-2
- EC Name:
- Boric acid
- Cas Number:
- 10043-35-3
- Molecular formula:
- H3BO3
- IUPAC Name:
- Boric acid
- Details on test material:
- - Name of test material: Boric acid
- Analytical purity: > 99 %
Constituent 1
Results and discussion
Any other information on results incl. tables
No clear and constant effect was noted on skin barrier function following boric acid application.
Applicant's summary and conclusion
- Conclusions:
- The influence of repeated and single exposure to boric acid on the skin barrier was investigated in vitro using static diffusion cells from cryopreserved human abdominal skin from 7 female donors. No clear and constant effect was noted on skin barrier function following boric acid application.
Read-across is justified on the basis detailed in the rationale for reliability above. This study is therefore considered to be of sufficient adequacy and reliability to be used as a supporting study and no further testing is justified.
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