Registration Dossier
Registration Dossier
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EC number: 825-571-0 | CAS number: 60428-79-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.24 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- December 2015 (REG (EC) No. 440/2008 amended by REG (EC) No. 2016/266)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- April 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Version / remarks:
- August 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 7.5
- Temp.:
- 35 °C
- pH:
- 7
- Remarks on result:
- not measured/tested
- Remarks:
- extrapolated value after re-evaluation (see attached report: "Estimation of the bioconcentration factor of Sakuralube S-600").
- Type:
- log Pow
- Partition coefficient:
- > 7.2
- Temp.:
- 35 °C
- pH:
- 7
- Remarks on result:
- other: note: the temperature refers to the column temperature
- Details on results:
- In the chromatogram of the test item solution, two peaks with a retention time of 22.4 and 22.8 minutes were observed. Under the same analytical conditions, the retention time of benzo[ghi]perylene (log Pow = 7.2) was 18.1 minutes. Thus, it was concluded that the log Pow of test item was > 7.2.
For details see attached document "S-600 - Log Pow.pdf"
In a re-evaluation in December 2021, the log Pow value was accurately determined by extrapolation. Herefore, in accordance with the OECD 117 guideline, a linear correlation between the log of the capacity factor and the log Pow was assumed. For more details on the extrapolation see section “Discussion of the HPLC determination” in the attached report “Extrapolation of the bioconcentration factor Sakuralube S-600”. - Conclusions:
- The extrapolated log Pow value of 7.5 was used for further assessment.
Reference
Description of key information
Extrapolated Log Pow = 7.5 at 35°C (column temperature, HPLC method) (OECD 117, EU A.24, OPPTS 830.7570)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 7.5
- at the temperature of:
- 35 °C
Additional information
Log Kow (Log Pow) > 7.2 at the temperature of 35°C (column temperature)
Re-Evaluation 2021: Extrapolation of Log Kow = 7.5 (see attached report: "Estimation of the bioconcentration factor of Sakuralube S-600")
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