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EC number: 262-810-2 | CAS number: 61477-95-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26.10.2018-
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 301B
- Version / remarks:
- Toxicity control
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
Test Item : Monalazone Disodium
Physical appearance : White or off white powder or crystals
Lot No. : 72617S
% Total Active Ingredient : >99% excluding water
Molecular formula : C7H4ClNNa2O4S
Molecular weight : 279.602 g/mol
Manufactured date : 26 July 2017
Expiry date : 01 February 2019
Recommended storage condition : Ambient (+18 to +36 °C)
pH : 8-10
Notes: a) Date of receipt of test item at test facility: 22 September 2018
b) Test Item code by test facility: H017-01- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Details on test solutions:
- Stock Solutions
All chemicals were of either analytical or better grade reagents:
Stock Solution Chemical Quantity (g)
A Potassium dihydrogen orthophosphate, KH2PO4 (AR) 4.2516
Dipotassium hydrogen orthophosphate, K2HPO4 (AR) 10.8731
Disodium hydrogen orthophosphate dihydrate, Na2HPO4.2H2O (AR) 16.7017
Ammonium chloride, NH4Cl (AR) 0.2518
These four constituents were dissolved in and made up to 500 mL using Milli-Q water. The pH of the solution was 7.53
B
Calcium chloride, dihydrate, CaCl2.2H2O (AR) 18.2011
This was dissolved in and made up to 500 mL using Milli-Q water.
C
Magnesium sulphate heptahydrate, MgSO4.7H2O (ExcelaR) 11.2511
This was dissolved in and made up to 500 mL using Milli-Q water.
D Iron (III) chloride hexahydrate, FeCl3.6H2O (AR) 0.1256
This was dissolved in and made up to 500 mL using Milli-Q water.
The test medium for test flasks 1 to 6, was prepared by mixing 24 mL of stock solution A with 1920 mL of Milli-Q water, then 2.4 mL each of stock solutions B, C and D was added and finally the volume was made up to 2400 mL using Milli-Q water in each flask.
Similarly, for Flask 7, 3000 mL of test medium was prepared by mixing 30 mL of stock solution A with 2400 mL of Milli-Q water, then 3 mL each of stock solutions B, C and D was added and finally the volume was made up to 3000 mL with Milli-Q water.
The pH of the test medium was in the range of 7.51 to 7.55. - Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- The inoculum was a secondary effluent, collected from a treatment plant receiving predominantly domestic sewage. This effluent was used as test system as it is recommended in the guideline. A fresh sample of secondary effluent was collected from the treatment plant and was kept aerobic during transport.
This effluent was allowed to settle for one hour, decanted and the decanted effluent was used in the test.
Source of the Inoculum
Sewage Treatment Plant
Eurofins Advinus Limited
Bengaluru – 560 058
India
Determination of Bacterial Population in the Inoculum
The bacterial population in the inoculum was determined as colony forming units (CFU/mL) by diluting the inoculum to an appropriate dilution and then plating on nutrient agar plates.
Preconditioning of the Inoculum
The decanted effluent was preconditioned by aerating for 5 days at 22 to 24C.
The bacterial population in the inoculum was 6.0 x 107 CFU/L. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 14 d
- Hardness:
- not specified
- Test temperature:
- 22-24 C
- pH:
- 7.81-7.87
- Dissolved oxygen:
- not specified
- Salinity:
- not specified
- Conductivity:
- not specified
- Nominal and measured concentrations:
- 10-20 mg/L
- Reference substance (positive control):
- yes
- Key result
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 20 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Details on results:
- • There was 38.63% degradation [based on ThCO2] in the toxicity control flask on day 13, which is in accordance with the guideline requirement that, in a toxicity test, containing both the test item and a reference item, if less than 25% ThCO2 occurs within 14 days, the test substance can be assumed to be inhibitory. This shows that the test item is not inhibitory to the test system.
- Results with reference substance (positive control):
- • There was 38.63% degradation [based on ThCO2] in the toxicity control flask on day 13, which is in accordance with the guideline requirement that, in a toxicity test, containing both the test item and a reference item, if less than 25% ThCO2 occurs within 14 days, the test substance can be assumed to be inhibitory. This shows that the test item is not inhibitory to the test system.
- Validity criteria fulfilled:
- yes
- Conclusions:
- in a toxicity test, containing both the test item and a reference item, if less than 25% ThCO2 occurs within 14 days, the test substance can be assumed to be inhibitory. This shows that the test item is not inhibitory to the test system.
- Executive summary:
in a toxicity test, containing both the test item and a reference item, if less than 25% ThCO2 occurs within 14 days, the test substance can be assumed to be inhibitory. This shows that the test item is not inhibitory to the test system.
Reference
Description of key information
in a toxicity test, containing both the test item and a reference item, if less than 25% ThCO2 occurs within 14 days, the test substance can be assumed to be inhibitory. This shows that the test item is not inhibitory to the test system.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 20 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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