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EC number: 214-022-5 | CAS number: 1073-05-8
The calculated IVIS for each replicate and the corresponding means are presented in the following table:
Relative Standard Deviation IVIS
Test Item1,3,2-Dioxathiane, 2,2-dioxide
Thisin vitrostudy was performed to assess corneal damage potential of1,3,2-Dioxathiane, 2,2-dioxideby quantitative measurements of changes in opacity and permeability in a bovine cornea.
Two experiments were performed. The first experiment was not valid, because the mean IVIS value of the negative control was too high. Therefore the experiment was declared invalid and repeated. This experiment is not reported, but the raw data are kept in the GLP-archive of the test facility. The second performed experiment was valid and reported.
The test item1,3,2-Dioxathiane, 2,2-dioxidewas brought onto the cornea of a bovine eye which previously had been incubated with cMEM without phenol red at 32 ± 1 °C for 1 hour and whose opacity had been determined. The test item was incubated on the cornea for 4 hoursat32 ± 1 °C. After removal of the test item, opacity and permeability values were measured.
The test item was tested neat. Under the conditions of this test, the test item1,3,2-Dioxathiane, 2,2-dioxideinduced serious eye damage on the cornea of the bovine eye. The calculated mean IVIS was 106.38.
According to OECD Guideline no. 437 (Oct. 2017), a substance with an IVIS > 55 induces serious eye damage, that should be classified as UN GHS Category I.
The negative control (HBSS) and the positive control (20% imidazole solution) have met the validity criteria.
No observations were made which might cause doubts concerning the validity of the study outcome. The test is considered valid.
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