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The test substance was evaluated for sensitization potential by applying 0.4 mL at a 100% concentration directly into Hilltop chmabers and applying them to the clipped left shoulder of twenty albino guinea pigs. The animals were held gently, and the chambers were applied as quickly as possible to the clipped left shoulder. The chmabers were secured with Micropore and Kendall adhesive tape. Approximatley 6 hours later, the tape and chambers were removed. Two additional indction doses were conducted following the same procedure, at weekly intervals.
Two weeks after the final application the animals received a topical primay challenge dose (6 hour contact) of the test material at 75% concentration, on a naive site located on the right shoulder. Animals were scored for irritation at 24 and 48 houts after initiation of the primary challenge application.
Ten guinea pigs served as a naive control group, and remained untreated through the induction phase. Six naive control animals received only the primary challenge dose, at a 75% concentration. The four remaining guinea pigs were designated for a re-challenge, if necessary.
Follwoing primary challenge at 75% concentration, the incidene of grade 1 responses or greater in the test group (0 of 20) was compared to that of the naive control group (0 of 6). The incidence and severity of these resposnes were not significantly greater than those produced by the naive control group indicating that sensitization had not been induced.
Under the classification criteria set forth under GHS, the test substance is not considered to be a skin sensitizer.
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