Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-207-6 | CAS number: 104-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates โ in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06 Jun 2018 to 21 Jun 2018.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation))
- Version / remarks:
- OECD Guideline 209. "Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation)โ, adopted 22 July 2010.
- Deviations:
- yes
- Remarks:
- See "Any other information" for details
- GLP compliance:
- yes
- Specific details on test material used for the study:
- No further details specifed in the study report.
- Analytical monitoring:
- not specified
- Vehicle:
- yes
- Details on test solutions:
- The batch of PPDI tested consisted of white chips and had a purity of 99.8%. No correction was made for the purity/composition of the test item.
The test item was not sufficiently soluble to allow preparation of an aqueous solution at a concentration of 10 g/L. Therefore, weighed amounts were added to the amber test bottles containing 200 mL Milli-RO water (tap water purified by reverse osmosis; Millipore Corp., Bedford, Mass., USA). The test item โ Milli-RO water mixtures were magnetically stirred for a short period. Subsequently, 16 mL synthetic medium made up to 50 mL with Milli-RO water and 250 mL sludge were added resulting in the required concentrations. Optimal contact between test item and test organisms was ensured by applying continuous aeration and stirring.
Any residual volumes were discarded. - Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- Test system: Micro-organisms in activated sludge.
Source: Municipal sewage treatment plant: 'Waterschap Aa en Maas','s -Hertogenbosch, Heeswijk-Dinther, The Netherlands, receiving predominantly domestic sewage.
Preparation of the sludge: The sludge was coarsely sieved (1 mm) and allowed to settle. The supernatant was removed and ISO-medium was added. A small amount of the sludge was weighed and dried overnight at ca. 105ยฐC to determine the amount of suspended solids (3.0 g/L of sludge, as used for the test). The pH was 7.0 on the day of testing. The batch of sludge was used one day after collection; therefore 50 mL of synthetic medium (=sewage feed) was added per litre of activated sludge at the end of the collection day. The sludge was kept aerated at test temperature until use.
Medium Adjusted ISO-medium, formulated using RO water (tap water purified by reverse osmosis; GEON Waterbehandeling, Berkel-Enschot, The Netherlands) with the following composition:
CaCl2.2H2O 211.5 mg/L
MgSO4.7H2O 88.8 mg/L
NaHCO3 46.7 mg/L
KCl 4.2 mg/L
Rationale: Recognized by international guidelines as the recommended test system. - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Post exposure observation period:
- No post exposure observation period specified in the study report.
- Hardness:
- Not specified
- Test temperature:
- 18 and 21ยฐC
- pH:
- 6.8 and 7.8.
- Dissolved oxygen:
- Not applicable - respiration inhibition study
- Salinity:
- Not applicable
- Conductivity:
- Not specified
- Nominal and measured concentrations:
- Final Test โ Test Concentrations
Paraphenylene diisocyanate (PPDI) Five concentrations: 100, 180, 320, 560 and 1000 mg/L. - Details on test conditions:
- Testing Strategy and Experimental Design
Combined Limit/Range-Finding Test
In a combined limit/range-finding test concentrations of 10, 100 and 1000 mg/L were tested.
The highest concentration was tested in triplicate, lower concentrations consisted of one replicate. In addition, a control (6 replicates) and an abiotic control (1 replicate) were tested.
Test procedure and conditions were similar to those applied in the final test with the following exceptions:
-The pH of the sludge was 5.8 on the day of testing. The sludge was buffered to a pH of 7.5 using a 70 g/L sodium bicarbonate solution. Before the sludge was used, the respiration rate of the sludge was determined to verify the quality of the sludge. The mean respiration rate of the sludge was 27 mg O2/g.h and within the validity criterion.
Final Test
Replicates: 5 replicates per test group and 6 replicates for the control.
Control: Test medium without test item, treated in the same way as the test item solutions.
Test Procedure and Conditions
Contact time: 3 hours, during which aeration and stirring took place. Vessels All glass open bottles/vessels.
Milli-RO / Milli-RO water: Tap water purified by reverse osmosis (Millipore Corp., Bedford, Mass., USA).
Synthetic medium 16 g peptone
(=sewage feed) 11 g meat extract
3 g urea
0.7 g NaCl
0.4 g CaCl2.2H2O
0.2 g MgSO4.7H2O
2.8 g K2HPO4
Dissolved in Milli-RO water, made up to 1 litre and filtered. The pH was within 7.5 ยฑ 0.5.
Air supply: Clean, oil-free air.
Aeration: The aeration was adjusted in such a way that the dissolved oxygen concentration at the start was above 60-70% saturation (60% of air saturation is > 5 mg/L at 20ยฐC) and to maintain the sludge flocs in suspension.
Performance of the test: The synthetic medium (16 mL) made up to 50 mL with Milli- RO and 200 mL test item solution were mixed (total volume 250 mL). The pH was determined. Thereafter, 250 mL activated sludge was added. This was the start of the test.
After the 3-hour contact time the oxygen consumption was recorded for a period of approximately 10 minutes. During measurement, the sample was not aerated but continuously stirred on a magnetic stirrer.
The pH was determined in the remaining part of the reaction mixture. This procedure was repeated for all test/reference item concentrations and controls.
The medium temperature was recorded continuously in temperature control vessels. The temperature control vessels were identically prepared compared to the control vessels. A temperature control vessel with a REES sensor was placed in each fume cupboard of the climate room.
Oxygen recording: Determination of oxygen was performed with multiple oxygen sensors connected to a BlueBox (GO-Systemelektronik GmbH, Germany), a multichannel measuring and controlling system. - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol.
- Key result
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 320 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Details on results:
- RESULTS
Combined Limit/Range-Finding Test
The combined limit/range-finding showed no inhibition of the respiration rate at 10 and 100 mg/L. At 1000 mg/L, 21% inhibition of the respiration rate was observed. Therefore, the expected EC50 was above 1000 mg/L. There was no oxygen uptake from abiotic processes.
Since the effect observed at 1000 mg/L was statistically significant a final test was performed to determine the NOEC.
All test conditions and acceptability criteria prescribed by the study plan were met.
Final Test
Inhibition of the Respiration Rate
The effects observed were in agreement with what was expected based on the results of the combined limit/range-finding test. The results of this test allowed for reliable determination of a NOEC and ECx values.
No statistically significant inhibition of the respiration rate of the sludge was recorded at or below 320 mg PPDI per liter. Replicate 5 at 560 mg/L was determined to be an outlier (see Appendix 3) and was not used in the statistical calculations. - Results with reference substance (positive control):
- The batch of activated sludge was tested for sensitivity with the reference item 3,5-dichlorophenol, and showed normal sensitivity.
- Reported statistics and error estimates:
- Test Item - Shapiro-Wilkยดs Test on Normal Distribution
Number of residuals = 30
Shapiro-Wilkยดs W = 0.961
p(W) = 0.332
p(W) is greater than the selected significance level of 0.010; thus treatment data do not significantly deviate from normal distribution. Normality check was passed (p > 0.01).
Test Item - Leveneยดs Test on Variance Homogeneity (with Residuals)
The Levene test indicates variance homogeneity (p > 0.010).
Variance homogeneity check was passed (p > 0.01).
Normal-distribution and variance-homogeneity requirements are fulfilled. A parametric multiple test is advisable.
Test Item - Determination of NOEC: Williams Multiple Sequential t-test Procedure.
A NOEC of 320 mg/L is suggested by the program. - Validity criteria fulfilled:
- yes
- Conclusions:
- In conclusion, under the conditions of the present test Paraphenylene diisocyanate (PPDI) was not toxic to waste water bacteria (activated sludge) at or below a concentration of 320 mg/L (NOEC).
The EC10 was 401 mg/L (95% confidence interval: 264 - 609 mg/L).
The EC20 was 823 mg/L (95% confidence interval: 601 - 1126 mg/L).
The EC50 was above 1000 mg/L. - Executive summary:
The objective of the study was to evaluate Paraphenylene diisocyanate (PPDI) for its ability to adversely affect aerobic microbial treatment plants and, if possible, to determine the EC50 and/or the no - observed effect concentration (NOEC).
The influence of PPDI on the respiration rate of activated sludge was investigated after a contact time of 3 hours.
The study procedures described in this report were based on the OECD guideline No. 209, 2010.
The batch of PPDI tested consisted of white chips and had a purity of 99.8%. No correction was made for the purity/composition of the test item.
The test item was not sufficiently soluble to allow preparation of an aqueous solution at a concentration of 10 g/L. Therefore, weighed amounts were added to the test bottles containing Milli-RO water. The test item โ Milli-RO water mixtures were magnetically stirred for a short period. Subsequently, synthetic medium, sludge and Milli - RO water were added resulting in the required concentrations. Optimal contact between test item and test medium was ensured by applying continuous aeration and stirring during the 3-hour exposure period. Thereafter, oxygen consumption was recorded for approximately 10 minutes.
The final test was performed based on the result of a preceding combined limit/range-finding test. Five concentrations were tested, ranging from 100 mg/L to 1000 mg/L and increasing with a factor 1.8. Five replicates per concentration and six replicates for an untreated control group were tested.
No statistically significant inhibition of the respiration rate of the sludge was recorded at 320 mg PPDI per liter. At the two higher concentrations the inhibitory effect of PPDI on aerobic waste water (activated sludge) bacteria increased with increasing concentration, with 13% inhibition at 560 mg/L and 24% at 1000 mg/L.
The batch of activated sludge was tested for sensitivity with the reference item 3,5-dichlorophenol, and showed normal sensitivity.
The study met the acceptability criteria prescribed by the study plan and was considered valid.
PPDI was not toxic to waste water (activated sludge) bacteria at or below a concentration of 320 mg/L (NOEC).
The effect parameters for the inhibition of the respiration rate are presented below.
Parameter
PPDI
Concentration (mg/L)
NOEC
320
EC10
401 (264 - 609)
EC20
823 (601 - 1126 )
EC50
>1000
( ) Between brackets the 95% confidence intervals are given.
Reference
Final Test โ Overview of the Results
Treatment |
Concentration (mg/L) |
Mean respiration rate |
% Inhibition of the respiration rate (mean value) |
|
(mg O2/L h) |
(mg O2/g h)ยน |
|||
Control |
0 |
33.63 |
22.42 |
|
T1 |
100 |
35.08 |
23.38 |
-4.30 |
T2 |
180 |
31.14 |
20.76 |
7.40 |
T3 |
320 |
32.26 |
21.51 |
4.07 |
T4 |
560 |
29.24 |
19.49 |
13.06* |
T5 |
1000 |
25.52 |
17.02 |
24.10* |
ยน) The amount of suspended solids in the final test mixture was 1.5 g/L.
* Statistically significantly different compared to control.
Effect
Parameters
Parameter |
PPDI Concentration (mg/L) |
NOEC |
320 |
EC10 |
401 (264 - 609) |
EC20 |
823 (601 - 1126) |
EC50 |
>1000 |
( ) Between brackets the 95% confidence intervals are given.
Combined
Limit/Range-Finding Test โ Respiration Rate/Inhibition, pH Values
Replicate |
Concentration (mg/L) |
pH |
Respiration rate |
% Inhibition respiration rate (mean value) |
||
Start |
End |
(mg O2/L.h) |
(mg O2/g.h)ยน |
|||
C 1 |
0 |
7.7 |
7.8 |
37.49 |
24.99 |
|
C 2 |
0 |
7.7 |
7.8 |
25.91 |
17.27 |
|
C 3 |
0 |
7.6 |
7.7 |
34.72 |
23.15 |
|
C 4 |
0 |
7.6 |
7.7 |
34.91 |
23.27 |
|
C 5 |
0 |
7.6 |
7.6 |
36.55 |
24.37 |
|
C 6 |
0 |
7.6 |
7.6 |
32.76 |
21.84 |
|
C Mean |
|
|
|
33.72 |
22.48 (RC) |
|
SD |
|
|
|
4.16 |
2.77 |
|
CV (%) |
|
|
|
12 |
12 |
|
|
|
|
|
|
|
|
R 1 |
1.0 |
7.7 |
8.0 |
29.65 |
19.77 |
12.08 |
R 2 |
3.2 |
7.7 |
8.2 |
16.92 |
11.28 |
49.83 |
R 3 |
10 |
7.7 |
8.2 |
10.18 |
6.79 |
69.81 |
R 4 |
32 |
7.7 |
8.2 |
4.53 |
3.02 |
86.57 |
|
|
|
|
|
|
|
T 1 |
10 |
7.7 |
7.8 |
34.76 |
23.17 |
-3.07 |
T 2 |
100 |
7.7 |
7.8 |
35.89 |
23.93 |
-6.42 |
T 3a |
1000 |
7.6 |
7.8 |
26.42 |
17.61 |
21.66 |
T 3b |
1000 |
7.6 |
7.7 |
27.12 |
18.08 |
19.58 |
T 3c |
1000 |
7.6 |
7.8 |
26.04 |
17.36 |
22.78 |
T3 Mean |
|
|
26.53 |
17.68 (RT)* |
21.34 (IT) |
|
|
|
|
|
|
|
|
TA |
1000 |
7.6 |
7.4 |
0.00# |
0.00 |
100.00 |
C: Control
R: Reference item, 3,5-dichlorophenol
T: Test item, PPDI
TA: Abiotic control of PPDI
SD: Standard deviation
CV: Coefficient of variation
RT: Total respiration with PPDI
RC: Total respiration in the control
IT: % inhibition of total respiration relative to RC
ยน The amount of suspended solids in the final test mixture was 1.5 g/L.
* Statistically significantly different compared to control
# No respiration, therefore expressed as 0 mg O2/L.h
Final
Test โRespiration
Rate/Inhibition, pH Values
|
Concentration (mg/L) |
pH |
Respiration rate |
% Inhibition respiration rate (mean value) |
||
Start |
End |
(mg O2/L.h) |
(mg O2/g.h)ยน |
|||
C 1 |
0 |
7.3 |
7.2 |
31.00 |
20.67 |
|
C 2 |
0 |
7.3 |
7.1 |
34.88 |
23.25 |
|
C 3 |
0 |
7.3 |
7.0 |
31.62 |
21.08 |
|
C 4 |
0 |
7.3 |
7.0 |
34.91 |
23.27 |
|
C 5 |
0 |
7.3 |
6.9 |
35.27 |
23.51 |
|
C 6 |
0 |
7.3 |
6.9 |
34.10 |
22.73 |
|
C Mean |
|
|
|
33.63 |
22.42 (RC) |
|
SD |
|
|
|
1.85 |
1.23 |
|
CV (%) |
|
|
|
5 |
5 |
|
|
|
|
|
|
|
|
R 1 |
1.0 |
7.3 |
7.6 |
27.06 |
18.04 |
19.54 |
R 2 |
3.2 |
7.3 |
7.8 |
15.20 |
10.13 |
54.80 |
R 3 |
10 |
7.3 |
7.7 |
8.79 |
5.86 |
73.86 |
R 4 |
32 |
7.3 |
7.7 |
3.38 |
2.25 |
89.95 |
|
|
|
|
|
|
|
T 1a |
100 |
7.3 |
7.0 |
34.58 |
23.05 |
-2.82 |
T 1b |
100 |
7.3 |
7.1 |
33.02 |
22.01 |
1.81 |
T 1c |
100 |
7.3 |
7.1 |
34.05 |
22.70 |
-1.25 |
T 1d |
100 |
7.3 |
- |
36.98 |
24.65 |
-9.96 |
T 1e |
100 |
7.3 |
- |
36.75 |
24.50 |
-9.28 |
T 1 Mean |
|
|
|
35.08 |
23.38 (RT) |
-4.30 (IT) |
|
|
|
|
|
|
|
T 2a |
180 |
7.3 |
7.1 |
32.34 |
21.56 |
3.84 |
T 2b |
180 |
7.3 |
7.1 |
28.80 |
19.20 |
14.36 |
T 2c |
180 |
7.3 |
7.1 |
29.36 |
19.57 |
12.70 |
T 2d |
180 |
7.3 |
7.1 |
31.92 |
21.28 |
5.08 |
T 2e |
180 |
7.3 |
7.0 |
33.29 |
22.19 |
1.01 |
T 2 Mean |
|
|
|
31.14 |
20.76 (RT) |
7.40 (IT) |
C: Control
SD: Standard deviation
CV: Coefficient of variation
R: Reference item, 3,5-dichlorophenol
T: Test item, PPDI
ยน: The amount of suspended solids in the final test mixture was 1.5 g/L
RC: Total respiration in the control
RT: Total respiration with PPDI
IT: % inhibition of total respiration relative to RC
-: No pH measurement, see deviation inError! Reference source not found.
Final
Test โ Respiration Rate/Inhibition, pH Values (continued)
Replicate |
Concentration (mg/L) |
pH |
Respiration rate |
% Inhibition respiration rate (mean value) |
||
Start |
End |
(mg O2/L.h) |
(mg O2/g.h)ยน |
|||
T 3a |
320 |
7.3 |
6.9 |
31.01 |
20.67 |
7.79 |
T 3b |
320 |
7.3 |
6.9 |
34.72 |
23.15 |
-3.24 |
T 3c |
320 |
7.3 |
7.0 |
27.79 |
18.53 |
17.37 |
T 3d |
320 |
7.3 |
6.9 |
35.91 |
23.94 |
-6.78 |
T 3e |
320 |
7.3 |
6.9 |
31.87 |
21.25 |
5.23 |
T 3 Mean |
|
|
|
32.26 |
21.51 (RT) |
4.07 (IT) |
|
|
|
|
|
|
|
T 4a |
560 |
7.3 |
7.0 |
23.97 |
15.98 |
28.72 |
T 4b |
560 |
7.3 |
6.8 |
33.31 |
22.21 |
0.95 |
T 4c |
560 |
7.3 |
7.0 |
29.22 |
19.48 |
13.11 |
T 4d |
560 |
7.3 |
6.9 |
30.45 |
20.30 |
9.46 |
T 4e |
560 |
7.3 |
7.0 |
5.94 2 |
3.96 2 |
82.34 |
T 4 Mean |
|
|
|
29.24 |
19.49 (RT)* |
13.06 (IT) |
|
|
|
|
|
|
|
T 5a |
1000 |
7.3 |
6.9 |
23.72 |
15.81 |
29.47 |
T 5b |
1000 |
7.3 |
6.9 |
29.05 |
19.37 |
13.62 |
T 5c |
1000 |
7.3 |
6.9 |
29.19 |
19.46 |
13.20 |
T 5d |
1000 |
7.3 |
6.9 |
25.72 |
17.15 |
23.52 |
T 5e |
1000 |
7.3 |
6.9 |
19.94 |
13.29 |
40.71 |
T 5 Mean |
|
|
|
25.52 |
17.02 (RT)* |
24.10 (IT) |
T: Test item PPDI
ยน: The amount of suspended solids in the final test mixture was 1.5 g/L
RT: Total respiration with PPDI
IT: % inhibition of total respiration relative to RC
*: Statistically significantly different compared to control
2: This replicate is an outlier and is not used for calculations of the NOEC and ECx values.
Description of key information
Paraphenylene diisocyanate (PPDI) was not toxic to waste water bacteria (activated sludge) at or below a concentration of 320 mg/L (NOEC).
The EC10 was 401 mg/L (95% confidence interval: 264 - 609 mg/L).
The EC20 was 823 mg/L (95% confidence interval: 601 - 1126 mg/L).
The EC50 was above 1000 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
- EC10 or NOEC for microorganisms:
- 320 mg/L
Additional information
The test item was not sufficiently soluble to allow preparation of an aqueous solution at a concentration of 10 g/L. Therefore, weighed amounts were added to the test bottles containing Milli-RO water. The test item โ Milli-RO water mixtures were magnetically stirred for a short period. Subsequently, synthetic medium, sludge and Milli - RO water were added resulting in the required concentrations. Optimal contact between test item and test medium was ensured by applying continuous aeration and stirring during the 3-hour exposure period. Thereafter, oxygen consumption was recorded for approximately 10 minutes.
The final test was performed based on the result of a preceding combined limit/range-finding test. Five concentrations were tested, ranging from 100 mg/L to 1000 mg/L and increasing with a factor 1.8. Five replicates per concentration and six replicates for an untreated control group were tested.
No statistically significant inhibition of the respiration rate of the sludge was recorded at 320 mg PPDI per liter. At the two higher concentrations the inhibitory effect of PPDI on aerobic waste water (activated sludge) bacteria increased with increasing concentration, with 13% inhibition at 560 mg/L and 24% at 1000 mg/L.
PPDI was not toxic to waste water (activated sludge) bacteria at or below a concentration of 320 mg/L (NOEC).
The effect parameters for the inhibition of the respiration rate are presented below.
Parameter |
PPDI Concentration (mg/L) |
NOEC |
320 |
EC10 |
401 (264 - 609) |
EC20 |
823 (601 - 1126 ) |
EC50 |
>1000 |
( ) Between brackets the 95% confidence intervals are given.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.