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EC number: 201-145-4 | CAS number: 78-81-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
One pre-OECD guideline and non-GLP in vivo skin irritation/corrosion study was conducted in rabbits. The skin of two animals were treated with 0.5 mL of undiluted isobutylamine during 1 hour under occlusive dressing.
Immediately after removal of the dressing, clear skin corrosive effects were noted on the application area.
No in vivo eye study was conducted due to the corrosive properties of the substance.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre-OECD guideline study and Non GLP study. Meets generally accepted scientific standards, well documented and acceptable for assessment.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Two animals treated simultenaously
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG
- Age at study initiation: not stated
- Weight at study initiation: 1.5 to 2.0 kg
- Housing: singly
- Diet: standard diet ERKA 8300 ad libitum
- Water: tap water ad libitum
- Acclimation period: not applicable
ENVIRONMENTAL CONDITIONS
no details reported
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL
- Duration of treatment / exposure:
- 1 hour
- Observation period:
- 1 hour
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: two areas, each 2.5 cm x 2.5 cm.
- Skin: intact and scarified
- Type of wrap if used: cotton gauze, covered by a PVC film, held in place by an elastic bandage.
REMOVAL OF TEST SUBSTANCE
- Washing: not stated
- removal of test patch: 1 hour after start of exposure
EVALUATION
- Time after start of exposure: 1 hour
SCORING SYSTEM: not defined - Irritation parameter:
- other: not evalutated due to obvious corrosion
- Basis:
- other: see above
- Time point:
- other: 1 hour post application
- Reversibility:
- not reversible
- Remarks on result:
- other: Deep skin corrosion; evalution of irritation parameters not needed
- Irritant / corrosive response data:
- Inspection of the intact skin test site after the 1-hour expsoure period revealed superficial chaps and colorless exsudation; pigmentation (green-brown-black) of the corroded skin; deep skin corrosion.
,, dark red erythema and deep skin corrosion was noted. - Other effects:
- Animals were excited 20 min past application and inactive thereafter.
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Remarks:
- Migrated information R 34 Criteria used for interpretation of results: other: EU, 67/548 EEC; Annex VI
- Conclusions:
- Isobutylamine caused full thickness corrosion of the the rabbit's skin within a 1-hour exposure period.
- Executive summary:
Isobutylamine caused full thickness corrosion of the rabbit's skin within a 1-hour exposure period in a valid non-GLP study conducted similar to OECD TG 404 (two Albino Himalayan rabbits tested; 0.5 mL undiluted test substance applied to intact skin) (Hoechst, 1979).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the above stated assessment of the skin irritation/corrosion potential, isobutylamine does have to be classified as Skin corrosive Category 1B (H314Causes severe skin burns and eye
damage) according to CLP (Regulation (EC) No 1272/2008 Of the European parliament and of the Council.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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