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EC number: 201-145-4
CAS number: 78-81-9
One pre-OECD guideline and non-GLP in vivo skin irritation/corrosion
study was conducted in rabbits. The skin of two animals were treated
with 0.5 mL of undiluted isobutylamine during 1 hour under occlusive
Immediately after removal of the dressing, clear skin corrosive effects
were noted on the application area.
No in vivo eye study was conducted due to the corrosive properties of
caused full thickness corrosion of the rabbit's skin within a 1-hour
exposure period in a valid non-GLP study conducted similar to OECD TG
404 (two Albino Himalayan rabbits tested; 0.5 mL undiluted test
substance applied to intact skin) (Hoechst, 1979).
on the above stated assessment of the skin irritation/corrosion
potential, isobutylamine does have to be classified as Skin corrosive
Category 1B (H314Causes
severe skin burns and eye
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