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EC number: 701-290-8
CAS number: -
The test article, sucrose acetate isobutyrate (SAIB) was evaluated for
its potential to induce ocular irritation in rabbits. The physical
characteristics of SAIB, as received, made it unsuitable for dosing in
this study. A solution was prepared by dissolving 1.0 gram of the test
article in 1.0 mL of corn oil and warming the solution to 32° C. The
solution was administered at a volume of 0.1 mL/eye, to each of the six
eyes (3 unwashed, 3 washed) utilized in this study. An additional eye
(unwashed) was dosed with 0.1 mL of corn oil to serve as a control. In
the control eye, no signs of irritation were observed during the 72-hour
observation period. When tested with fluorescein dye 24 hours after
dosing, no adnexal or corneal staining was noted. The test ardcle was a
slight eye irritant when administered as a 50% solution in corn oil. In
unwashed eyes, signs of irritation were limited to moderate erythema of
the conjunctivae and nictitating membranes one hour after administration
of the test material. At the 24-hour observation period, one of three
unwashed eyes appeared normal and slight erythema of the conjunctivae
and nictitating membranes were noted in the remaining two eyes. When
tested with fluorescein dye 24 hours after dosing, there was no adnexal
or corneal staining in the unwashed eyes. By 48 hours, two of three eyes
were normal and by 72 hours, all unwashed eyes appeared clinically
normal. Immediate washing reduced the duration of irritation were
restricted to slight erythema of the conjunctivae and nictitating
membranes at the one-hour observation period. At 24 hours, all washed
eyes appeared normal and no corneal or adnexal staining was observed
when the eyes were tested with fluorescein dye.
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