Registration Dossier
Registration Dossier
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EC number: 701-290-8 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sucrose di(acetate) hexaisobutyrate
- EC Number:
- 204-771-6
- EC Name:
- Sucrose di(acetate) hexaisobutyrate
- Cas Number:
- 126-13-6
- IUPAC Name:
- Sucrose Acetate Isobutyrate
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- A dose of 0.5 mL was applied to each depilated guinea pig abdomen.
- Duration of treatment / exposure:
- An occlusive wrap was used to hold the test material against the skin for 24 hours.
- Observation period:
- 14 days
- Number of animals:
- 5
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other: The score was not counted. The results were evalauted based on as slight, moderate and stong efefct levels
- Irritation parameter:
- edema score
- Time point:
- 24/48/72 h
- Score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Sucrose Acetate Isobutyrate (SAIB) is non-irritating to guinea pig skin.
- Executive summary:
A dose of 0.5 mL of Sucrose Acetate Isobutyrate (SAIB) was applied to each depilated abdomen of 5 guinea pigs, and an occlusive wrap was used to hold the test material against the skin for 24 hours. No signs of irritation were observed over the 14-day observation period. All animals gained weight normally, and based on weight gain and survival rate, no signs of percutaneous absorption were evident.
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