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Diss Factsheets
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EC number: 284-634-5 | CAS number: 84961-45-5 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Ceratonia siliqua. Leguminosae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 18 Sep 2017 to 11 Oct 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2001
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- soil
Test material
- Test material form:
- liquid
- Details on test material:
- - Physical appearance: Dark brown to black liquid
- Storage of test material: At room temperature
Constituent 1
- Radiolabelling:
- no
Study design
- Test temperature:
- Column temperature: 35°C ± 1°C
HPLC method
- Details on study design: HPLC method:
- JUSTIFICATION
The test item is a UVCB, therefore the HPLC method was performed (at pH 7).
HPLC CONDITIONS
- Apparatus: Acquity UPLC system (Waters, USA)
- Column: Acquity UPLC HSS Cyano, 100 mm x 2.1 mm i.d., dp = 1.8 µm (Waters)
- Injection volume: 5 μL
- Detector: Acquity UPLC TUV (Waters)
- UV detection: 210 nm
MOBILE PHASE
- Type: buffered mobile phase
- Preparation of buffer pH 7: Solution of 0.01 M potassium di-hydrogenphosphate in water adjusted to pH 7 using 1N sodium hydroxide. Sodium azide content: 0.0009% (w/v). Type of water: Tap water purified by a Milli-Q water purification system.
- Composition: 55/45 (v/v) methanol/buffer pH 7
- Flow: 0.4 mL/min
DETERMINATION OF DEAD TIME
Not conducted.
REFERENCE SUBSTANCES
- Identity: Acetanilide (log Koc 1.26).
- A solution of the reference substance was prepared in 55/45 (v/v) methanol/buffer pH 7 from a stock solution (1 g/L) in methanol.
TEST ITEM
A 550 mg/L test item solution was prepared in 55/45 (v/v) methanol/buffer pH 7 from a stock solution (1000 mg/L) in methanol.
DETERMINATION OF RETENTION TIMES
- Duplicate injections of the reference substance and test item.
- Single injection of the blank (55/45 (v/v) methanol/buffer pH 7).
Results and discussion
Adsorption coefficient
- Key result
- Type:
- log Koc
- Value:
- < 1.26 dimensionless
- pH:
- 7
- Temp.:
- 20 °C
Results: HPLC method
- Details on results (HPLC method):
- Retention time of acetanilide (log Koc 1.26): 1.038 minutes.
In the chromatogram of the test item solution, two major peaks with a mean retention time of 0.435 and 0.489 minutes and one small peak with a retention time of 0.677 minutes were observed.
Any other information on results incl. tables
Table: result HPLC method - adsorption coefficient (Koc)
|
Koc |
log Koc |
Peak area (%) |
Test item – peak 1 |
< 18 |
< 1.26 |
35 |
Test item – peak 2 |
< 18 |
< 1.26 |
61 |
Test item – peak 3 |
< 18 |
< 1.26 |
3.5 |
Applicant's summary and conclusion
- Conclusions:
- The log Koc of the substance at pH 7 was estimated to be < 1.26 (Koc< 1.8E01).
- Executive summary:
The HPLC estimation method was used for the determination of the adsorption coefficient (Koc) of the substance. The study was performed in accordance with EC C.19 and OECD 121 and in compliance with GLP. The mobile phase was 55/45 (v/v) methanol/buffer pH 7 and the wavelength of detection was 210 nm. The stationary phase contained cyanopropyl chains chemically bonded to silica. One reference substance was used: acetanilide (log Koc 1.26 based on soil-adsorption reference data). Duplicate injections of the test item and reference substance. In the chromatogram of the test item solution, two major peaks with a mean retention time of 0.435 and 0.489 minutes and one small peak with a retention time of 0.677 minutes were observed. The mean (n=2) retention time of acetanilide was 1.038. From this it was concluded that the log Koc of the substance is < 1.26 (Koc < 1.8E01).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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