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Diss Factsheets
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EC number: 272-823-5 | CAS number: 68916-18-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- other: Expert assessment
- Adequacy of study:
- weight of evidence
- Study period:
- March 22 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was carried out based on the experimental data on target substance constituents and their toxicokinetic behavior.
Data source
Reference
- Reference Type:
- other: expert assessment
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An expert assessment was performed for the substance to assess its sensitizing potential based on experimental data on its constituents identified in the literature, their toxicokinetic behaviour, and historical uses of the substance and its constituents.
- GLP compliance:
- no
- Type of study:
- other: in vitro
Test material
- Reference substance name:
- Coffee, bean, roasted, ext.
- EC Number:
- 272-823-5
- EC Name:
- Coffee, bean, roasted, ext.
- Cas Number:
- 68916-18-7
- IUPAC Name:
- Coffee, bean, roasted, ext.
- Test material form:
- liquid: viscous
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Key result
- Parameter:
- other: sensitizing properties based on the evaluation of the the intrinsic properties for the main components of the substance
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- It has been concluded that based on the long history of use in food and cosmetics, as well as the intrinsic properties for the main components of Coffee, bean, roasted, ext. (water, polysaccharides, fibers and other polymers), no skin sensitization is expected.
- Executive summary:
An expert assessment was performed for Coffee, bean, roasted, ext. to assess its sensitizing potential based on experimental data on its constituents identified in the literature, their toxicokinetic behaviour, and historical uses of the substance and its constituents.
It has been concluded that based on the long history of use in food and cosmetics, as well as the intrinsic properties for the main components of Coffee, bean, roasted, ext. (water, polysaccharides, fibers and other polymers), no skin sensitization is expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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