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Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Testing was conducted between 6 August 2018 and 8 August 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The study was conducted according to an internationally recognised method, and under GLP. The test substance is adequately characterised. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 103 (Boiling Point)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.2 (Boiling Temperature)
Version / remarks:
2008
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
Inspected on 4,5 and 6 July 2016/ Signed on 10 January 2017
Type of method:
differential scanning calorimetry
Key result
Boiling pt.:
355 °C
Atm. press.:
101.3 kPa

Results

All the raw data (calibration, pre-test and main tests) is in the experimental report.

Pre-study

The initial boiling point of the substance was observed at 365.2°C.

Temperature program:

Step

Initial temperature (°C)

Final Temperature (°C)

Heating rate (°C/min)

Duration (min)

Furnace atmosphere

Rate* (mL/min)

Liquid nitrogen cooling

1

-120

480

10

60

He

60

NO

*Gas injection rate in the furnace.

Test 1:

Mass taken: 11.98 mg

Initial boiling point was observed at 352.2°C (onset temperature of the peak) and a corresponding mass loss was observed on the TG curve, showing that almost all the substance was evaporated at the end of the study.

The crucible was visually checked after the determination. The lid hole has been slightly obstructed during the boiling. By opening the crucible, a small quantity of the test item left on the crucible wall and became black.

Atmospheric pressure: 97.7 kPa

Test 2:

Mass taken: 10.87 mg

Initial boiling point was observed at 357.4°C (onset temperature of the peak) and a corresponding mass loss was observed on the TG curve, showing that almost all the substance was evaporated at the end of the study.

The crucible was visually checked after the determination and the same observations as for the first determination were noticed.

Atmospheric pressure: 97.7 kPa.

Test 3:

Mass taken: 12.37 mg

Initial boiling point was observed at 353.9°C (onset temperature of the peak) and a corresponding mass loss was observed on the TG curve, showing that almost all the substance was evaporated at the end of the study.

The crucible was visually checked after the determination and the same observations as for the two first determinations were noticed.

Atmospheric pressure: 97.8 kPa.

Apparatus Check

Temperature

Expected melting point: 156.6 +/- 0.5°C

Obtained melting point: 156.5°C

The melting point of the Indium respects the defined tolerance of the expected melting point.

Sensitivity

Expected enthalpy: 28.6 +/- 2.9 J/g

Obtained enthalpy: 29.75 J/g

The enthalpy of the indium respects the defined tolerance of the expected enthalpy.

Conclusion

The initial boiling point of the test item was determined to be 352.2°C at 97.7 kPa for the first determination and 353.9°C at 97.8 kPa for the third determination. The corrected values following Sidney-Young equation were determined to be 355.0°C (mean of 354.1°C at 101.3 kPa for the first determination and 355.8°C at 101.3 kPa for the third determination).

Conclusions:
The corrected value following Sidney-Young equation was determined to be 355.0°C.
Executive summary:

The study was performed in order to determine the boiling point of test item according to OECD 103, resp. EU A.2, using the DSC method.

3 trials were performed. The initial boiling point of the test item was determined to be 352.2°C at 97.7 kPa for the first determination and 353.9°C at 97.8 kPa for the third determination. The corrected values following Sidney-Young equation were determined to be 355.0°C (mean of 354.1°C at 101.3 kPa for the first determination and 355.8°C at 101.3 kPa for the third determination).

Description of key information

The initial boiling point of the substance was determined as 355.0°C at 101.3 kPa

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
355 °C

Additional information

A fully reliable experimental study, conducted according to OECD 103/ EU A2 guideline is available.

It is considered as a key study, and the result is retained as key data.