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EC number: 442-390-9 | CAS number: 40573-09-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
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- Flash point
- Auto flammability
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- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
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- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Nanomaterial pour density
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- Endpoint summary
- Stability
- Biodegradation
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
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- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 December 2001 to 20 December 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with GLP regulations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EC method B.1 (1996)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Perfluormethoxypropylvinylether
- IUPAC Name:
- Perfluormethoxypropylvinylether
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Perfluormethoxypropylvinylether
- Substance type: Clear, colorless liquid
- Physical state: Liquid
- Purity test date: 30 July 2000
- Lot/batch no.: Lot 3
- Storage condition of test material: Darkness at 5 °C in a refrigerator under nitrogen atmosphere
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Minkelmann GmbH
Gartenstrasse 27
D-33178 Borchen
- Age at study initiation: 6-10 weeks
- Weight at study initiation: Males: 198-199 g, Females: 172-184 g
- Fasting period before study: No details other than "fasted"
- Housing: 3 animals per cage in transparent macrolon (type IV) cages
- Diet (e.g. ad libitum): Ssniff R/M-H (V 1534), ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25
- Humidity (%): 30-70
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 04 December 2001 To: 20 December 2001
Administration / exposure
- Route of administration:
- oral: gavage
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 2000 mg/kg body weight.
DOSAGE PREPARATION: The test article was administered undiluted.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: The dose was chosen based on toxicicty data or related compounds. - Doses:
- A single 2000 mg/kg bw dose was administered to the test group animals.
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical signs were recorded twice a day, body weights were recorded on Days 1, 8, and 15.
- Necropsy of survivors performed: yes, macroscopic
- Other examinations performed: clinical signs, body weights
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: A single 2000 mg/kg bw dose was administered by oral gavage.
- Mortality:
- No mortality occurred during the study.
- Clinical signs:
- other: On study Day 1, stilted gait was observed in 1 animal and a squatting posture in 2 animals. No other clinical signs were observed in any other animals at any time points.
- Gross pathology:
- No macroscopically visible changes were observed.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Conclusions:
- Based on the results of the study, the oral LD50 of the test substance is > 2000 mg/kg body weight.
- Executive summary:
The acute oral toxicity of the test article was determined in Sprague Dawley rats. The study was conducted in compliance with OECD GLP (1999). The test method was based on OECD Guideline 423 (1996) and EC Method B.1 (1996). Rats (3/sex) were administered a single dose of 2,000 mg/kg body weight of undiluted test article by oral gavage. Body weights (Days 1, 8, and 15) and clinical signs (twice daily) were recorded. No mortality occurred during the study, and body weight gain was not impaired. On study Day 1, stilted gait was observed in 1 animal and a squatting posture in 2 animals. No other clinical signs were observed in any other animals at any time points. Based on the results of the study, the oral LD50 of the test article is > 2000 mg/kg body weight.
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