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EC number: 948-766-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1995/07/28-1995/09/08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to or similar to guideline study OECD 403: GLP
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1995/07/28-1995/09/08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to or similar to guideline study OECD 403: GLP
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 266 mg/m³ air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: No mortality occurred.
- Mortality:
- No mortality in either Group 1 or Group 2.
- Clinical signs:
- other: During exposure, animals in both Group 1 and Group 2 exhibited material on fur, decreased activity and closed eyes. Some animals in Group 2 displayed clear nasal discharge. Upon removal from chamber, animals in both groups displayed decreased activity, t
- Body weight:
- All animals displayed increased in body weight over their initial (Day 0) values, with the exception of two females in Group 2 that had slight weight losses.
- Gross pathology:
- All Group 1 animals were free of abnormalities at the gross postmortem evaluation.
In Group 2, 4 males/1 female exhibited red foci and/or slight discoloration on the lungs, 1 male displayed dark red nasal turbinates, 1 male had smaller than normal right kidney, and 3 males/1 female exhibited alopecia and/or scabs on the dorsal surface, extremities and/or head. - Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 for acute inhalation exposure (aerosol atmosphere) of MRD-95-247 is greater than 5266 mg/m3 (5213 mg/m3 aerosol, 53 mg/m3 vapor). This finding does not warrant classification of MRD-95-247 as an acute inhalation toxicant under the new Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
- Executive summary:
This data is being read across from the source study that tested Hydrocarbons, C10-C12, isoalkanes, <2% aromatics based on analogue read across.
To assess acute inhalation toxicity, MRD-95 -247 was administered via individual whole-body inhalation chambers for four hours to two groups of ten Crl:CDBR rats at either an estimated aerosol concentration of 5247 mg/m3 or an analytical concentration of 5266 mg/m3 (5213 mg/m3 aersol, 53 mg/m3 vapor). Animals were observed for fourteen days following exposure. No mortality was observed, and all animals that received the estimated aerosol concentration of 5247 mg/m3 were free of gross pathological abnormalities. In the second group (5266 mg/m3 aerosol), 4 males and 1 female exhibited red foci on the lungs, one male displayed dark red nasal turbinates, and 3 males and 1 female had alopecia and/or scabs on the dorsal surface, extremities, and/or head. Based on the conditions of this study, the LC50 for acute inhalation exposure to an aerosol atmosphere of MRD-95 -247 is greater than 5266 mg/m3.
This finding does not warrant classification of MRD-95-247 as an acute inhalation toxicant under the new Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Hydrocarbons, C10-C12, isoalkanes, <2% aromatics
- EC Number:
- 923-037-2
- Molecular formula:
- (CH2)6-8C4H10
- IUPAC Name:
- Hydrocarbons, C10-C12, isoalkanes, <2% aromatics
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl: CDBR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Kingston Facility, Stone Ridge, New York
- Age at study initiation: Group 1, approximately 6-7 weeks; Group 2, approximately 8-9 weeks
- Weight at study initiation: Group 1 males, 182 to 208 grams; Group 1 females, 171 to 184 grams; Group 2 males, 315 to 339 grams; Group 2 females, 220 to 232 grams
- Fasting period before study: none
- Housing: Single housed during study period, suspended stainless steel and wire mesh
- Diet (e.g. ad libitum): Certified Rodent Diet #5002 from PMI Feeds, Inc. Richmond, Indiana, ad libitum during non-exposure periods. Food was withheld while animals were in chamber.
- Water (e.g. ad libitum): Automatic watering system, ad libitum during non-exposure periods. Water withheld while animals were in chamber.
- Acclimation period: At least 12 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 68-76 degrees F in animal room; 70-74 degrees F in exposure chamber
- Humidity (%): 40-70% relative humidity in animal room; 58-73% relative humidity in exposure chamber
- Photoperiod (hrs dark / hrs light): 12 hours light/12 hours dark
IN-LIFE DATES: From: 1995-08-08 To: 1995-09-08
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: 150 liter stainless steel and acrylic whole-body inhalation exposure chamber
- System of generating particulates/aerosols: The test material was generated using a single-barrel Laskin nebulizer and a 3-neck round-bottom flask as a reservoir for the liquid test material. Compressed air was supplied to the nebulizer at approximately 3.5-4.0 psi back-pressure, producing a liquid droplet aerosol atmosphere within the 3-neck flask. The aerosol mixed with additional room air which was drawn through a glass mixing vessel prior to entering the exposure chamber.
- Method of particle size determination: The particle size distribution was determined once during each exposure using a Sierra Instruments Model 210 Cascade Impactor. Pre-weighed glass fiber filters were used to collect the aerosol on each stage. A bulk estimation technique was employed to characterize the particle size distribution of the atmosphere. The change in weight of the filter for each stage was measured and the cumulative percent of the sample collected on each stage was calculated. This information plus the stage constants for the impactor were used to calculate the 15.9%, 50.0%, and 84.1% particle sizes (equivalent aerodynamic diameter), the geometric standard deviation, and the estimated percent of the aerosol less than or equal to 1, 10, and 15 microns in size.
- Temperature, humidity, pressure in air chamber: Chamber airflow, temperature, and relative humidity were monitored continuously throughout the exposure and recorded approximately every 30 minutes.
TEST ATMOSPHERE
- Brief description of analytical method used: Analytical chamber concentrations were determined during each hour of the exposure by drawing a known volume of the test atmosphere through a sample train consisting of pre-weighed teflon (PTFE) (Group 1) or glass fiber (Group 2) filters for non-volatile aerosol and a charcoal sorbent tube for volatile hydrocarbons.
From Group 1, the filters were first weighed for gravimetric determination of total non-volatile aerosol; the analytical procedure then specified analyis of both filters and sorbent tubes by GC/FID for total and individual hydrocarbons. However, the filters were not weighed until 8 days after the exposure and it appeared that a significant portion of the collected test material had volatilized from the fibers. Exposure was repeated with a second group of animals.
From Group 2, non-volatile aerosol was collected on a glass-fiber filter and the gravimetric determination was performed immediately following sample collection. The filters and sorbent tube were analyzed by GC/FID, and total hydrocarbons and individual hydrocarbons (full scan) were reported as the sum of the gravimetric aerosol and total hydrocarbon vapor results.
PARTICLE SIZE DATA
-Mass median equivalent aerodynamic diameter (50% size): Group 1 and Group 2, 3.7 microns
-Geometric standard deviation: Group 1, 2.9; Group 2, 2.5
-Percent <= 15 microns: Group 1, 91%; Group 2, 93.5%
-Percent <= 10 microns: Group 1, 83%; Group 2, 85.9%
-Percent <= 1 micron: Group 1, 10.6%, Group 2, 8.3% - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetrically (aerosol); GC/FID (vapor)
- Duration of exposure:
- 4 h
- Concentrations:
- Group 1: estimated aerosol concentration of 5247 mg/m3
Group 2: analytical chamber concentration of 5266 mg/m3 (5213 mg/m3 aerosol, 53 mg/m3 vapor) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: At 15 minute intervals during the first hour of exposure and once each hour thereafter through the termination of exposure.
- Necropsy of survivors performed: yes - Statistics:
- Statistical analyses included means and standard deviations of body weight and body weight change by group and sex.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 266 mg/m³ air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: No mortality occurred.
- Mortality:
- No mortality in either Group 1 or Group 2.
- Clinical signs:
- other: During exposure, animals in both Group 1 and Group 2 exhibited material on fur, decreased activity and closed eyes. Some animals in Group 2 displayed clear nasal discharge. Upon removal from chamber, animals in both groups displayed decreased activity, t
- Body weight:
- All animals displayed increased in body weight over their initial (Day 0) values, with the exception of two females in Group 2 that had slight weight losses.
- Gross pathology:
- All Group 1 animals were free of abnormalities at the gross postmortem evaluation.
In Group 2, 4 males/1 female exhibited red foci and/or slight discoloration on the lungs, 1 male displayed dark red nasal turbinates, 1 male had smaller than normal right kidney, and 3 males/1 female exhibited alopecia and/or scabs on the dorsal surface, extremities and/or head.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 for acute inhalation exposure (aerosol atmosphere) of MRD-95-247 is greater than 5266 mg/m3 (5213 mg/m3 aerosol, 53 mg/m3 vapor). This finding does not warrant classification of MRD-95-247 as an acute inhalation toxicant under the new Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
- Executive summary:
To assess acute inhalation toxicity, MRD-95 -247 was administered via individual whole-body inhalation chambers for four hours to two groups of ten Crl:CDBR rats at either an estimated aerosol concentration of 5247 mg/m3 or an analytical concentration of 5266 mg/m3 (5213 mg/m3 aersol, 53 mg/m3 vapor). Animals were observed for fourteen days following exposure. No mortality was observed, and all animals that received the estimated aerosol concentration of 5247 mg/m3 were free of gross pathological abnormalities. In the second group (5266 mg/m3 aerosol), 4 males and 1 female exhibited red foci on the lungs, one male displayed dark red nasal turbinates, and 3 males and 1 female had alopecia and/or scabs on the dorsal surface, extremities, and/or head. Based on the conditions of this study, the LC50 for acute inhalation exposure to an aerosol atmosphere of MRD-95 -247 is greater than 5266 mg/m3.
This finding does not warrant classification of MRD-95-247 as an acute inhalation toxicant under the new Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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